Hydrazonoyl chlorides possess promising antitumor properties.

Animals Antineoplastic Agents / chemical synthesis Apoptosis / drug effects Cell Line, Tumor / drug effects Cell Proliferation / drug effects Cell Survival / drug effects Chlorides / chemistry DNA Repair Enzymes / metabolism Drug Screening Assays, Antitumor / methods Female Humans Hydrazones / chemical synthesis Male Mice Mice, Inbred BALB C PTEN Phosphohydrolase / metabolism Phosphatidylinositol 3-Kinases / metabolism Phosphotransferases (Alcohol Group Acceptor) / metabolism Proto-Oncogene Proteins c-akt / metabolism Signal Transduction / drug effects TOR Serine-Threonine Kinases / metabolism
Ehrlich ascities carcinoma Hydrazonoyl chlorides PI3K/AKT/mTOR PNKP PTEN Synthetic lethality

Journal

Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521

Informations de publication

Date de publication:
15 Apr 2022
Historique:
received: 22 09 2021
revised: 01 02 2022
accepted: 02 02 2022
pubmed: 11 2 2022
medline: 12 3 2022
entrez: 10 2 2022
Statut: ppublish

Résumé

the main purpose of this study was to identify new selective antitumor agents. several hydrazonoyl chlorides (HCs) were synthesized and human tumor cell line viability was determined using the MTT assay. Tumor development was assessed using Ehrlich ascites carcinoma (EAC)-bearing mice. our results showed that 2-oxo-N-phenyl-2-(phenylamino)acetohydrazonoyl chloride (compound 4; CPD 4) and 2-oxo-2-(phenylamino)-N-(p-tolyl)acetohydrazonoyl chloride (CPD 5) were the most cytotoxic HCs to human cervical tumor HeLa (IC hydrazonoyl chlorides can be considered as hit compounds for the development of new antitumor agents.

Identifiants

DOI: 10.1016/j.lfs.2022.120380 PMID: 35143825
pubmed: 35143825
pii: S0024-3205(22)00080-7
doi: 10.1016/j.lfs.2022.120380
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Chlorides 0
Hydrazones 0
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
Proto-Oncogene Proteins c-akt EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1
PTEN Phosphohydrolase EC 3.1.3.67
DNA Repair Enzymes EC 6.5.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120380

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Mohamed A M El Gendy (MAM)

Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt. Electronic address: elgendy@ualberta.ca.

Hamdy Hassanein (H)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Fatma M Saleh (FM)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Feridoun Karimi-Busheri (F)

Experimental Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

Mesfin Fanta (M)

Experimental Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

Xiaoyan Yang (X)

Experimental Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

Doaa Tawfik (D)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Shorouk Morsy (S)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Merna Fahmy (M)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Mahmoud Hemid (M)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Mohamed Abdel Azeiz (M)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Ahmed Fared (A)

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Michael Weinfeld (M)

Experimental Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Enzymes de réparation de l'ADN › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › Hydrazones › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Phosphohydrolase PTEN › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Hydrazonoyl chlorides possess promising...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Hydrazonoyl chlorides possess promising...