Michael Weinfeld

Affiliations

Division of Experimental Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.

Publications (32)

Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk.

Frontiers in oncology

Avec: Li Jin , Fan Shen , Michael Weinfeld , Consolato Sergi

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP.

Journal of virology

Avec: Malgorzata Rychlowska , Abigail Agyapong , Michael Weinfeld , Luis M Schang

Loss of the DNA repair protein, polynucleotide kinase/phosphatase, activates the type 1 interferon response independent of ionizing radiation.

Nucleic acids research

Avec: Wisdom Deebeke Kate , Mesfin Fanta , Michael Weinfeld

Computer-aided drug design of small molecule inhibitors of the ERCC1-XPF protein-protein interaction.

Chemical biology & drug design

Avec: Francesco Gentile , Ahmed H Elmenoufy , Gloria Ciniero , David Jay , Feridoun Karimi-Busheri , Khaled H Barakat , Michael Weinfeld , Frederick G West , Jack A Tuszynski

RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line.

International journal of molecular sciences

Avec: Huachen Chen , Powel Crosley , Abul K Azad , Nidhi Gupta , Nisha Gokul , Zhihua Xu , Michael Weinfeld , Lynne-Marie Postovit , Stephanie A Pangas , Mary M Hitt , YangXin Fu

Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs).

European journal of medicinal chemistry

Avec: Hassan Rh Elsaidi , Xiao-Hong Yang , Fatemeh Ahmadi , Michael Weinfeld , Leonard I Wiebe , Piyush Kumar

Detection of Uracil-Excising DNA Glycosylases in Cancer Cell Samples Using a Three-Dimensional DNAzyme Walker.

ACS measurement science au

Avec: Jeffrey Tao , Hongquan Zhang , Michael Weinfeld , X Chris Le

Personalized treatment approach for HER2-positive metastatic breast cancer.

Medical oncology (Northwood, London, England)

Avec: Prashant Pandey , Rishabh Chaudhary , Devika Tripathi , Kousalya Lavudi , Kamal Dua , Michael Weinfeld , Afsaneh Lavasanifar , P S Rajinikanth

CDK-Dependent Phosphorylation Regulates PNKP Function in DNA Replication.

The Journal of biological chemistry

Avec: Fatemeh Mashayekhi , Elham Zeinali , Cassandra Ganje , Mesfin Fanta , Lei Li , Roseline Godbout , Michael Weinfeld , Ismail Hassan Ismail

Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy.

Pharmaceutics

Avec: Sams M A Sadat , Mohammad Reza Vakili , Igor M Paiva , Michael Weinfeld , Afsaneh Lavasanifar

A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Sams M A Sadat , Igor M Paiva , Zahra Shire , Forughalsadat Sanaee , Timothy D R Morgan , Marco Paladino , Feridoun Karimi-Busheri , Rajam S Mani , Gary R Martin , Frank R Jirik , Dennis G Hall , Michael Weinfeld , Afsaneh Lavasanifar

Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins.

Redox biology

Avec: Faisal Bin Rashed , Alexandru Cezar Stoica , Dawn MacDonald , Hassan El-Saidi , Carolynne Ricardo , Bhumi Bhatt , Jack Moore , Diana Diaz-Dussan , Nirilanto Ramamonjisoa , Yvonne Mowery , Sambasivarao Damaraju , Richard Fahlman , Piyush Kumar , Michael Weinfeld

Modulation of ERCC1-XPF Heterodimerization Inhibition

Frontiers in oncology

Avec: Claudia Weilbeer , David Jay , James C Donnelly , Francesco Gentile , Feridoun Karimi-Busheri , Xiaoyan Yang , Rajam S Mani , Yaping Yu , Ahmed H Elmenoufy , Khaled H Barakat , Jack A Tuszynski , Michael Weinfeld , Frederick G West

Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3'-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer.

Molecular pharmaceutics

Avec: Sams M A Sadat , Mohammad Reza Vakili , Sara I Abd-El Hafeez , Marco Paladino , Dennis G Hall , Michael Weinfeld , Afsaneh Lavasanifar

Domain analysis of PNKP-XRCC1 interactions: Influence of genetic variants of XRCC1.

The Journal of biological chemistry

Avec: Rajam S Mani , Inbal Mermershtain , Ismail Abdou , Mesfin Fanta , Michael J Hendzel , J N Mark Glover , Michael Weinfeld

Synthesis and Analysis of

Molecular pharmaceutics

Avec: Igor Paiva , Stephanie Mattingly , Melinda Wuest , Samantha Leier , Mohammad Reza Vakili , Michael Weinfeld , Afsaneh Lavasanifar , Frank Wuest

PNKP is required for maintaining the integrity of progenitor cell populations in adult mice.

Life science alliance

Avec: Wisoo Shin , Whitney Alpaugh , Laura J Hallihan , Sarthak Sinha , Emilie Crowther , Gary R Martin , Teresa Scheidl-Yee , Xiaoyan Yang , Grace Yoon , Taylor Goldsmith , Nelson D Berger , Luiz Gn de Almeida , Antoine Dufour , Ina Dobrinski , Michael Weinfeld , Frank R Jirik , Jeff Biernaskie

Biodistribution and Activity of EGFR Targeted Polymeric Micelles Delivering a New Inhibitor of DNA Repair to Orthotopic Colorectal Cancer Xenografts with Metastasis.

Molecular pharmaceutics

Avec: Igor Moura de Paiva , Mohammad Reza Vakili , Amir Hasan Soleimani , Seyed Amirhossein Tabatabaei Dakhili , Sirazum Munira , Marco Paladino , Gary Martin , Frank R Jirik , Dennis G Hall , Michael Weinfeld , Afsaneh Lavasanifar

Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents.

Redox biology

Avec: Faisal Bin Rashed , Diana Diaz-Dussan , Fatemeh Mashayekhi , Dawn Macdonald , Patrick Nicholas Nation , Xiao-Hong Yang , Sargun Sokhi , Alexandru Cezar Stoica , Hassan El-Saidi , Carolynne Ricardo , Ravin Narain , Ismail Hassan Ismail , Leonard Irving Wiebe , Piyush Kumar , Michael Weinfeld

A Sensitive Technique Unravels the Kinetics of Activation and Trans-Cleavage of CRISPR-Cas Systems.

Angewandte Chemie (International ed. in English)

Avec: Wei Feng , Hanyong Peng , Hongquan Zhang , Michael Weinfeld , X Chris Le

Optimized Carbohydrate-Based Nanogel Formulation to Sensitize Hypoxic Tumors.

Molecular pharmaceutics

Avec: Diana Diaz-Dussan , Yi-Yang Peng , Faisal Bin Rashed , Dawn Macdonald , Michael Weinfeld , Piyush Kumar , Ravin Narain

Enhancing the activity of platinum-based drugs by improved inhibitors of ERCC1-XPF-mediated DNA repair.

Cancer chemotherapy and pharmacology

Avec: Gloria Ciniero , Ahmed H Elmenoufy , Francesco Gentile , Michael Weinfeld , Marco A Deriu , Frederick G West , Jack A Tuszynski , Charles Dumontet , Emeline Cros-Perrial , Lars Petter Jordheim

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.

Journal of medicinal chemistry

Avec: Ahmed H Elmenoufy , Francesco Gentile , David Jay , Feridoun Karimi-Busheri , Xiaoyan Yang , Olivier M Soueidan , Claudia Weilbeer , Rajam S Mani , Khaled H Barakat , Jack A Tuszynski , Michael Weinfeld , Frederick G West

Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.

European journal of medicinal chemistry

Avec: Ahmed H Elmenoufy , Francesco Gentile , David Jay , Feridoun Karimi-Busheri , Xiaoyan Yang , Olivier M Soueidan , Rajam S Mani , Gloria Ciniero , Jack A Tuszynski , Michael Weinfeld , Frederick G West

Gold Nanorods are Selective Cytotoxic Agents.

Anti-cancer agents in medicinal chemistry

Avec: Mohamed El Gendy , Michael Weinfeld , Ahmed Abdoon

Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage.

Frontiers in oncology

Avec: Sams M A Sadat , Melinda Wuest , Igor M Paiva , Sirazum Munira , Nasim Sarrami , Forughalsadat Sanaee , Xiaoyan Yang , Marco Paladino , Ziyad Binkhathlan , Feridoun Karimi-Busheri , Gary R Martin , Frank R Jirik , David Murray , Armin M Gamper , Dennis G Hall , Michael Weinfeld , Afsaneh Lavasanifar

Hydrazonoyl chlorides possess promising antitumor properties.

Life sciences

Avec: Mohamed A M El Gendy , Hamdy Hassanein , Fatma M Saleh , Feridoun Karimi-Busheri , Mesfin Fanta , Xiaoyan Yang , Doaa Tawfik , Shorouk Morsy , Merna Fahmy , Mahmoud Hemid , Mohamed Abdel Azeiz , Ahmed Fared , Michael Weinfeld

Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor.

Scientific reports

Avec: Bingcheng Jiang , Cameron Murray , Bonnie L Cole , J N Mark Glover , Gordon K Chan , Jean Deschenes , Rajam S Mani , Sudip Subedi , John D Nerva , Anthony C Wang , Christina M Lockwood , Heather C Mefford , Sarah E S Leary , Jeffery G Ojemann , Michael Weinfeld , Chibawanye I Ene

Clustered DNA Damage and its Complexity: Tracking the History.

Radiation research

Avec: Dudley T Goodhead , Michael Weinfeld

Repurposing Antimalarial Pyronaridine as a DNA Repair Inhibitor to Exploit the Full Potential of Gold-Nanoparticle-Mediated Radiation Response.

Pharmaceutics

Avec: Nolan Jackson , Abdulaziz Alhussan , Kyle Bromma , David Jay , James C Donnelly , Frederick G West , Afsaneh Lavasanifar , Michael Weinfeld , Wayne Beckham , Devika B Chithrani

Influence of 2-Nitroimidazoles in the Response of FaDu Cells to Ionizing Radiation and Hypoxia/Reoxygenation Stress.

Antioxidants (Basel, Switzerland)

Avec: Faisal Bin Rashed , Wisdom Deebeke Kate , Mesfin Fanta , Leonard Irving Wiebe , Piyush Kumar , Michael Weinfeld

Development of a DNAzyme Walker for the Detection of APE1 in Living Cancer Cells.

Analytical chemistry

Avec: Jeffrey Tao , Hongquan Zhang , Michael Weinfeld , X Chris Le

Réseau de co-auteurs

Afsaneh Lavasanifar 8 collaborations

Feridoun Karimi-Busheri 7 collaborations

Frederick G West 6 collaborations

Rajam S Mani 6 collaborations

Xiaoyan Yang 6 collaborations

Mesfin Fanta 5 collaborations

Francesco Gentile 5 collaborations

Ahmed H Elmenoufy 5 collaborations

David Jay 5 collaborations

Jack A Tuszynski 5 collaborations

Piyush Kumar 5 collaborations

Sams M A Sadat 4 collaborations

Mohammad Reza Vakili 4 collaborations

Marco Paladino 4 collaborations

Frank R Jirik 4 collaborations

Dennis G Hall 4 collaborations

Faisal Bin Rashed 4 collaborations

Gloria Ciniero 3 collaborations

Khaled H Barakat 3 collaborations

Hongquan Zhang 3 collaborations

X Chris Le 3 collaborations

Igor M Paiva 3 collaborations

Gary R Martin 3 collaborations

Diana Diaz-Dussan 3 collaborations

Wisdom Deebeke Kate 2 collaborations

Xiao-Hong Yang 2 collaborations

Jeffrey Tao 2 collaborations

Fatemeh Mashayekhi 2 collaborations

Ismail Hassan Ismail 2 collaborations

Forughalsadat Sanaee 2 collaborations

Alexandru Cezar Stoica 2 collaborations

Hassan El-Saidi 2 collaborations

Carolynne Ricardo 2 collaborations

Claudia Weilbeer 2 collaborations

James C Donnelly 2 collaborations

J N Mark Glover 2 collaborations

Melinda Wuest 2 collaborations

Sirazum Munira 2 collaborations

Dawn Macdonald 2 collaborations

Ravin Narain 2 collaborations

Leonard Irving Wiebe 2 collaborations

Olivier M Soueidan 2 collaborations

Li Jin 1 collaboration

Fan Shen 1 collaboration

Consolato Sergi 1 collaboration

Malgorzata Rychlowska 1 collaboration

Abigail Agyapong 1 collaboration

Luis M Schang 1 collaboration

Huachen Chen 1 collaboration

Powel Crosley 1 collaboration

Abul K Azad 1 collaboration

Nidhi Gupta 1 collaboration

Nisha Gokul 1 collaboration

Zhihua Xu 1 collaboration

Lynne-Marie Postovit 1 collaboration

Stephanie A Pangas 1 collaboration

Mary M Hitt 1 collaboration

YangXin Fu 1 collaboration

Hassan Rh Elsaidi 1 collaboration

Fatemeh Ahmadi 1 collaboration

Leonard I Wiebe 1 collaboration

Prashant Pandey 1 collaboration

Rishabh Chaudhary 1 collaboration

Devika Tripathi 1 collaboration

Kousalya Lavudi 1 collaboration

Kamal Dua 1 collaboration

P S Rajinikanth 1 collaboration

Elham Zeinali 1 collaboration

Cassandra Ganje 1 collaboration

Lei Li 1 collaboration

Roseline Godbout 1 collaboration

Zahra Shire 1 collaboration

Timothy D R Morgan 1 collaboration

Dawn MacDonald 1 collaboration

Bhumi Bhatt 1 collaboration

Jack Moore 1 collaboration

Nirilanto Ramamonjisoa 1 collaboration

Yvonne Mowery 1 collaboration

Sambasivarao Damaraju 1 collaboration

Richard Fahlman 1 collaboration

Yaping Yu 1 collaboration

Sara I Abd-El Hafeez 1 collaboration

Inbal Mermershtain 1 collaboration

Ismail Abdou 1 collaboration

Michael J Hendzel 1 collaboration

Igor Paiva 1 collaboration

Stephanie Mattingly 1 collaboration

Samantha Leier 1 collaboration

Frank Wuest 1 collaboration

Wisoo Shin 1 collaboration

Whitney Alpaugh 1 collaboration

Laura J Hallihan 1 collaboration

Sarthak Sinha 1 collaboration

Emilie Crowther 1 collaboration

Teresa Scheidl-Yee 1 collaboration

Grace Yoon 1 collaboration

Taylor Goldsmith 1 collaboration

Nelson D Berger 1 collaboration

Luiz Gn de Almeida 1 collaboration

Antoine Dufour 1 collaboration

Ina Dobrinski 1 collaboration

Jeff Biernaskie 1 collaboration

Igor Moura de Paiva 1 collaboration

Amir Hasan Soleimani 1 collaboration

Seyed Amirhossein Tabatabaei Dakhili 1 collaboration

Gary Martin 1 collaboration

Patrick Nicholas Nation 1 collaboration

Sargun Sokhi 1 collaboration

Wei Feng 1 collaboration

Hanyong Peng 1 collaboration

Yi-Yang Peng 1 collaboration

Marco A Deriu 1 collaboration

Charles Dumontet 1 collaboration

Emeline Cros-Perrial 1 collaboration

Lars Petter Jordheim 1 collaboration

Mohamed El Gendy 1 collaboration

Ahmed Abdoon 1 collaboration

Nasim Sarrami 1 collaboration

Ziyad Binkhathlan 1 collaboration

David Murray 1 collaboration

Armin M Gamper 1 collaboration

Mohamed A M El Gendy 1 collaboration

Hamdy Hassanein 1 collaboration

Fatma M Saleh 1 collaboration

Doaa Tawfik 1 collaboration

Shorouk Morsy 1 collaboration

Merna Fahmy 1 collaboration

Mahmoud Hemid 1 collaboration

Mohamed Abdel Azeiz 1 collaboration

Ahmed Fared 1 collaboration

Bingcheng Jiang 1 collaboration

Cameron Murray 1 collaboration

Bonnie L Cole 1 collaboration

Gordon K Chan 1 collaboration

Jean Deschenes 1 collaboration

Sudip Subedi 1 collaboration

John D Nerva 1 collaboration

Anthony C Wang 1 collaboration

Christina M Lockwood 1 collaboration

Heather C Mefford 1 collaboration

Sarah E S Leary 1 collaboration

Jeffery G Ojemann 1 collaboration

Chibawanye I Ene 1 collaboration

Dudley T Goodhead 1 collaboration

Nolan Jackson 1 collaboration

Abdulaziz Alhussan 1 collaboration

Kyle Bromma 1 collaboration

Wayne Beckham 1 collaboration

Devika B Chithrani 1 collaboration