Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
06
09
2021
accepted:
08
12
2021
revised:
23
11
2021
pubmed:
12
2
2022
medline:
28
4
2022
entrez:
11
2
2022
Statut:
ppublish
Résumé
For the first time we have defined naïve, central memory, effector memory and differentiated effector porcine CD8 T cells and analyzed their distribution in lymphoid and respiratory tissues after influenza infection or immunization, using peptide-MHC tetramers of three influenza nucleoprotein (NP) epitopes. The hierarchy of response to the three epitopes changes during the response in different tissues. Most NP-specific CD8 T cells in broncho-alveolar lavage (BAL) and lung are tissue resident memory cells (TRM) that express CD69 and downregulate CD45RA and CCR7. NP-specific cells isolated from BAL express genes characteristic of TRM, but gene expression differs at 7, 21 and 63 days post infection. In all tissues the frequency of NP-specific CD8 cells declines over 63 days almost to background levels but is best maintained in BAL. The kinetic of influenza specific memory CD8 T cell in this natural host species differs from that in small animal models.
Identifiants
pubmed: 35145208
doi: 10.1038/s41385-021-00478-4
pii: S1933-0219(22)00065-4
pmc: PMC9038527
doi:
Substances chimiques
Epitopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
428-442Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L001330/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220295/Z/20/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007036
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P021336/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007031
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007038
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007037
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007039
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/0000703
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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