Five-year outcomes of premature infants randomized to high or standard loading dose caffeine.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
17
09
2021
accepted:
27
01
2022
revised:
05
01
2022
pubmed:
12
2
2022
medline:
14
5
2022
entrez:
11
2
2022
Statut:
ppublish
Résumé
To examine 5-year outcomes in children enrolled in a pilot randomized controlled trial of a high loading dose of caffeine after preterm birth. Seventy-four very low birth weight neonates were randomized within the first 24 h of life to receive a high (80 mg/kg) or standard (20 mg/kg) loading dose of caffeine citrate. At 5 years of age, we conducted standardized neurodevelopmental tests and collected parent reports of child socioemotional problems. Seventy-four percent of survivors returned for follow up. Children obtained similar scores on neurodevelopmental and socioemotional evaluations. There was no difference in the incidence of any neurodevelopmental delay after controlling for confounding factors. Five-year follow up of a pilot trial of high loading dose caffeine citrate documented no profound impacts on childhood neurodevelopment or socioemotional outcome.
Identifiants
pubmed: 35145209
doi: 10.1038/s41372-022-01333-5
pii: 10.1038/s41372-022-01333-5
pmc: PMC9098661
mid: NIHMS1775944
doi:
Substances chimiques
Caffeine
3G6A5W338E
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
631-635Subventions
Organisme : NINDS NIH HHS
ID : K02 NS089852
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH105179
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD055931
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD057098
Pays : United States
Organisme : NICHD NIH HHS
ID : F30 HD105336
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103525
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH122735
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113570
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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