Fibroblast Growth Factor 19 in Gestational Diabetes Mellitus and Fetal Growth.
Birth Weight
C-Peptide
/ blood
Case-Control Studies
Diabetes, Gestational
/ blood
Female
Fetal Blood
/ chemistry
Fetal Development
Fibroblast Growth Factors
/ blood
Humans
Infant, Newborn
Insulin-Like Growth Factor I
/ analysis
Insulin-Like Growth Factor II
/ analysis
Male
Pregnancy
Proinsulin
/ blood
C-peptide
fetal growth
fibroblast growth factor 19 (FGF19)
gestational diabetes (GD)
insulin
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
10
2021
accepted:
27
12
2021
entrez:
11
2
2022
pubmed:
12
2
2022
medline:
19
3
2022
Statut:
epublish
Résumé
Fibroblast growth factor 19 (FGF19) has been implicated in glucose homeostasis. Gestational diabetes mellitus (GDM) enhances fetal insulin secretion and fetal growth. Girls weigh less and are more insulin resistant than boys at birth. We sought to assess whether FGF19 is associated with GDM and fetal growth and explore potential sex dimorphic associations. This was a nested case-control study in the Shanghai Birth Cohort, including 153 pairs of newborns of GDM versus euglycemic mothers matched by infant's sex and gestational age at birth. Cord plasma FGF19, insulin, C-peptide, proinsulin, IGF-I and IGF-II concentrations were measured. Cord plasma FGF19 concentrations were similar in GDM versus euglycemic pregnancies (mean ± SD: 43.5 ± 28.2 versus 44.5 ± 30.2 pg/mL, P=0.38). FGF19 was not correlated with IGF-I or IGF-II. FGF19 concentrations were positively correlated with birth weight (r=0.23, P=0.01) and length (r=0.21, P=0.02) z scores, C-peptide (r=0.27, P=0.002) and proinsulin (r=0.27, P=0.002) concentrations in females. Each SD increment in cord plasma FGF19 was associated with a 0.25 (0.07-0.43) increase in birth weight z score in females. In contrast, FGF19 was not correlated with birth weight or length in males. These sex dimorphic associations remained after adjusting for maternal and neonatal characteristics. The study is the first to demonstrate that GDM does not matter for cord blood FGF19 concentrations. The female specific positive correlation between FGF19 and birth weight is suggestive of a sex-dimorphic role of FGF19 in fetal growth. The observations call for more studies to validate the novel findings and elucidate the underlying mechanisms.
Identifiants
pubmed: 35145481
doi: 10.3389/fendo.2021.805722
pmc: PMC8821646
doi:
Substances chimiques
C-Peptide
0
FGF19 protein, human
0
IGF1 protein, human
0
IGF2 protein, human
0
Fibroblast Growth Factors
62031-54-3
Insulin-Like Growth Factor I
67763-96-6
Insulin-Like Growth Factor II
67763-97-7
Proinsulin
9035-68-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
805722Subventions
Organisme : CIHR
ID : 158616
Pays : Canada
Informations de copyright
Copyright © 2022 Yang, Huang, Liu, Xu, Wang, He, Zhang, Zheng, Fang, Fan, Li, Zhang, Li, Ouyang and Luo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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