G protein-coupled receptors as regulators of pancreatic islet functionality.
G protein-coupled receptor
G-protein signaling
Hormone secretion
Islet development
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
14
10
2021
revised:
02
02
2022
accepted:
03
02
2022
pubmed:
14
2
2022
medline:
15
3
2022
entrez:
13
2
2022
Statut:
ppublish
Résumé
Glucose homeostasis is maintained by hormones secreted from different types of pancreatic islets and its dysregulation can result in diseases including diabetes mellitus. The secretion of hormones from pancreatic islets is highly complex and tightly controlled by G protein-coupled receptors (GPCRs). Moreover, GPCR signaling may play a role in enhancing islet cell replication and proliferation. Thus, targeting GPCRs offers a promising strategy for regulating the functionality of pancreatic islets. Here, available RNAseq datasets from human and mouse islets were used to identify the GPCR expression profile and the impact of GPCR signaling for normal islet functionality is discussed.
Identifiants
pubmed: 35151663
pii: S0167-4889(22)00026-X
doi: 10.1016/j.bbamcr.2022.119235
pii:
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119235Informations de copyright
Copyright © 2022 The Author. Published by Elsevier B.V. All rights reserved.