Iatrogenic ictal asystole.
Arrhythmia
Carbamazepine
Epilepsy
Faint
Phenytoin
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 Mar 2022
15 Mar 2022
Historique:
received:
12
11
2021
revised:
14
01
2022
accepted:
04
02
2022
pubmed:
14
2
2022
medline:
14
4
2022
entrez:
13
2
2022
Statut:
ppublish
Résumé
Sodium channels blockers are widely used in focal epilepsies. Beyond frequent and recognized adverse events, a possible influence in cardiac conduction has rarely been hypothesized. Cardiac asystolia is a rare complication of seizures: exact etiology is far from being clarified. Here we report two cases of focal pharmacoresistant epilepsy complicated by ictal asystole which occurred only in the course of treatment with carbamazepine and phenytoin. The clear relationship between ictal arrhythmia and sodium channels blockers may be related to the negative chronotropic and inotropic cardiac effects. Ictal asystole may exacerbate falls in epileptic populations and requires rapid therapeutic decisions. Iatrogenic causes must be added in the therapeutic algorithm.
Sections du résumé
BACKGROUND
BACKGROUND
Sodium channels blockers are widely used in focal epilepsies. Beyond frequent and recognized adverse events, a possible influence in cardiac conduction has rarely been hypothesized. Cardiac asystolia is a rare complication of seizures: exact etiology is far from being clarified.
METHOD AND RESULTS
RESULTS
Here we report two cases of focal pharmacoresistant epilepsy complicated by ictal asystole which occurred only in the course of treatment with carbamazepine and phenytoin.
CONCLUSIONS
CONCLUSIONS
The clear relationship between ictal arrhythmia and sodium channels blockers may be related to the negative chronotropic and inotropic cardiac effects. Ictal asystole may exacerbate falls in epileptic populations and requires rapid therapeutic decisions. Iatrogenic causes must be added in the therapeutic algorithm.
Identifiants
pubmed: 35151939
pii: S0022-510X(22)00045-4
doi: 10.1016/j.jns.2022.120183
pii:
doi:
Substances chimiques
Sodium Channels
0
Types de publication
Case Reports
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
120183Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.