Diversity of Dysregulated Long Non-Coding RNAs in HBV-Related Hepatocellular Carcinoma.
HBV-related HCC
ceRNA
epigenetic regulation
lncRNA
miRNA precursor processing
protein interactions
transcriptional regulation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
12
2021
accepted:
10
01
2022
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
29
3
2022
Statut:
epublish
Résumé
Infection with the hepatitis B virus (HBV) continues to pose a major threat to public health as approximately 292 million people worldwide are currently living with the chronic form of the disease, for which treatment is non-curative. Chronic HBV infections often progress to hepatocellular carcinoma (HCC) which is one of the world's leading causes of cancer-related deaths. Although the process of hepatocarcinogenesis is multifaceted and has yet to be fully elucidated, several studies have implicated numerous long non-coding RNAs (lncRNAs) as contributors to the development of HCC. These host-derived lncRNAs, which are often dysregulated as a consequence of viral infection, have been shown to function as signals, decoys, guides, or scaffolds, to modulate gene expression at epigenetic, transcriptional, post-transcriptional and even post-translational levels. These lncRNAs mainly function to promote HBV replication and oncogene expression or downregulate tumor suppressors. Very few lncRNAs are known to suppress tumorigenesis and these are often downregulated in HCC. In this review, we describe the mechanisms by which lncRNA dysregulation in HBV-related HCC promotes tumorigenesis and cancer progression.
Identifiants
pubmed: 35154157
doi: 10.3389/fimmu.2022.834650
pmc: PMC8831247
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
834650Informations de copyright
Copyright © 2022 Samudh, Shrilall, Arbuthnot, Bloom and Ely.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Oncotarget. 2016 May 3;7(18):25350-65
pubmed: 26992218
Cancer Res. 2015 Jun 1;75(11):2363-74
pubmed: 25855382
Hepatology. 2014 Oct;60(4):1278-90
pubmed: 25043274
J Biol Chem. 2012 Jul 27;287(31):26302-11
pubmed: 22685290
Mol Immunol. 2019 Dec;116:18-28
pubmed: 31574452
Mol Cell. 2011 Sep 16;43(6):904-14
pubmed: 21925379
J Biol Chem. 2014 Oct 17;289(42):29365-75
pubmed: 25187517
Oncotarget. 2015 Oct 20;6(32):33791-804
pubmed: 26393879
J Inflamm Res. 2021 Oct 23;14:5489-5500
pubmed: 34720597
Hum Cell. 2021 Nov;34(6):1830-1842
pubmed: 34487338
Oncotarget. 2016 Jul 5;7(27):42422-42430
pubmed: 27285756
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72
pubmed: 19571010
J Transl Med. 2016 Nov 28;14(1):328
pubmed: 27894309
J Hematol Oncol. 2015 May 14;8:50
pubmed: 25966845
Cancer Lett. 2019 Jul 10;454:158-170
pubmed: 30981758
Hepatology. 2014 Mar;59(3):911-23
pubmed: 24114970
Nucleic Acids Res. 2012 Aug;40(14):6391-400
pubmed: 22492512
Biomed Pharmacother. 2018 Nov;107:824-833
pubmed: 30142544
Biosci Trends. 2016 Sep 5;10(4):315-9
pubmed: 27499103
Hepatology. 2011 Nov;54(5):1679-89
pubmed: 21769904
EMBO J. 1991 May;10(5):1091-101
pubmed: 2022183
J Hepatol. 2016 Feb;64(2):278-291
pubmed: 26409216
iScience. 2018 Apr 27;2:210-220
pubmed: 29888750
Genes Dev. 2008 Mar 15;22(6):756-69
pubmed: 18347095
Oncotarget. 2015 Dec 15;6(40):42813-24
pubmed: 26540343
Mol Cell. 2001 Jun;7(6):1267-78
pubmed: 11430829
Sci Rep. 2019 Aug 12;9(1):11593
pubmed: 31406141
Science. 2014 Mar 14;343(6176):1221-8
pubmed: 24557838
J Oncol. 2021 Apr 28;2021:6627173
pubmed: 34007276
Gastroenterology. 2009 Mar;136(3):1012-24
pubmed: 19150350
Nucleic Acids Res. 2010 Sep;38(16):5366-83
pubmed: 20423907
J Biol Chem. 2000 Sep 8;275(36):27806-14
pubmed: 10842185
Cancer Lett. 2018 Aug 10;429:89-99
pubmed: 29753758
PLoS One. 2014 Oct 09;9(10):e109782
pubmed: 25299640
World J Gastroenterol. 2019 Jan 14;25(2):220-232
pubmed: 30670911
Biomed Pharmacother. 2017 Jun;90:100-108
pubmed: 28343069
Cell Biochem Biophys. 2020 Dec;78(4):465-474
pubmed: 32405957
Noncoding RNA. 2018 Aug 28;4(3):
pubmed: 30154386
Cancer Cell. 2004 May;5(5):465-75
pubmed: 15144954
Hepatology. 2013 May;57(5):1882-92
pubmed: 23239537
Mol Pathol. 1997 Feb;50(1):34-44
pubmed: 9208812
World J Gastroenterol. 2015 Jun 21;21(23):7208-17
pubmed: 26109807
PLoS One. 2015 Dec 16;10(12):e0144934
pubmed: 26674525
Gastroenterology. 2007 Jan;132(1):330-42
pubmed: 17241883
Nat Rev Genet. 2020 Feb;21(2):102-117
pubmed: 31729473
Biochem Biophys Res Commun. 2019 Jan 1;508(1):79-86
pubmed: 30471857
Genes Dev. 2006 May 1;20(9):1123-36
pubmed: 16618801
J Immunol. 2012 Jan 15;188(2):753-64
pubmed: 22174449
Cancer Lett. 2016 Nov 28;382(2):166-175
pubmed: 27597739
Oncol Lett. 2017 Aug;14(2):2025-2032
pubmed: 28789433
Carcinogenesis. 2013 Mar;34(3):577-86
pubmed: 23222811
Front Immunol. 2021 Aug 12;12:691766
pubmed: 34456908
Biomed Res Int. 2020 Apr 14;2020:8765461
pubmed: 32382578
Genome Res. 2002 Jun;12(6):894-908
pubmed: 12045143
Nat Commun. 2018 Oct 15;9(1):4268
pubmed: 30323189
Genes Chromosomes Cancer. 2004 Aug;40(4):285-97
pubmed: 15188451
Theranostics. 2020 Sep 1;10(24):10957-10972
pubmed: 33042264
Virus Genes. 2018 Aug;54(4):475-483
pubmed: 29789998
Annu Rev Immunol. 1995;13:29-60
pubmed: 7612225
Clin Cancer Res. 2006 Aug 15;12(16):4851-8
pubmed: 16914571
Br J Cancer. 2021 Nov 8;:
pubmed: 34750493
Gastroenterol Res Pract. 2018 Dec 4;2018:9187316
pubmed: 30622563
Cancers (Basel). 2021 Jun 22;13(13):
pubmed: 34206504
Int J Clin Exp Pathol. 2015 Mar 01;8(3):3076-82
pubmed: 26045820
Cell. 2007 Jun 29;129(7):1311-23
pubmed: 17604720
Oncotarget. 2017 Jun 30;8(39):65421-65434
pubmed: 29029442
Sci Rep. 2016 Mar 24;6:23521
pubmed: 27009634
Theranostics. 2019 Jul 9;9(18):5227-5245
pubmed: 31410212
Oncogene. 2018 Apr;37(14):1815-1829
pubmed: 29348457
Nature. 2011 Apr 7;472(7341):120-4
pubmed: 21423168
J Pathol. 2020 Apr;250(5):480-495
pubmed: 32100288
Biochimie. 2011 Nov;93(11):1935-42
pubmed: 21820484
Virol J. 2017 Dec 19;14(1):238
pubmed: 29258558
BMC Res Notes. 2012 Feb 06;5:87
pubmed: 22309575
Cell. 2008 Nov 28;135(5):919-32
pubmed: 19041754
Oncol Lett. 2016 Aug;12(2):1233-1239
pubmed: 27446422
Cell Death Discov. 2021 May 17;7(1):110
pubmed: 34001866
Cancer Manag Res. 2019 Jan 17;11:877-897
pubmed: 30697079
Cell. 2011 Aug 5;146(3):353-8
pubmed: 21802130
Am J Cancer Res. 2017 Apr 01;7(4):845-856
pubmed: 28469957
Tumour Biol. 2015 May;36(5):3231-6
pubmed: 25501706
Hepatology. 2021 Feb;73(2):503-519
pubmed: 32314410
Cancer Cell. 2010 Jan 19;17(1):28-40
pubmed: 20060366
PLoS One. 2008 Sep 22;3(9):e3255
pubmed: 18806873
J Biol Chem. 2010 Sep 24;285(39):30282-93
pubmed: 20624918
Biomed Pharmacother. 2019 Jul;115:108877
pubmed: 31054511
Cells. 2019 Sep 20;8(10):
pubmed: 31547193
Cell Death Dis. 2018 Dec 5;9(12):1184
pubmed: 30518748
Nutr Metab (Lond). 2021 Feb 23;18(1):22
pubmed: 33622377
Gut. 2020 Nov;69(11):2016-2024
pubmed: 32114505
Cancer Cell. 2014 Mar 17;25(3):335-49
pubmed: 24582836
Oncol Res. 2021 Mar 16;28(6):591-603
pubmed: 32838835
Hepatobiliary Surg Nutr. 2018 Dec;7(6):429-439
pubmed: 30652087
Science. 2010 Aug 6;329(5992):689-93
pubmed: 20616235
RNA. 2007 Mar;13(3):313-6
pubmed: 17237358
Cancer Res. 2006 May 15;66(10):5330-7
pubmed: 16707459
Hepatology. 2012 Dec;56(6):2231-41
pubmed: 22706893
Curr Opin Mol Ther. 2010 Oct;12(5):607-16
pubmed: 20886393
Bosn J Basic Med Sci. 2018 May 20;18(2):150-161
pubmed: 29669510
Cell. 2005 Jan 28;120(2):209-21
pubmed: 15680327
Oncol Rep. 2020 Feb;43(2):718-726
pubmed: 31894346
Hepatology. 2018 Dec;68(6):2130-2144
pubmed: 29790592
Virus Res. 2016 Jan 2;212:103-13
pubmed: 26239319
Clin Sci (Lond). 2020 Nov 27;134(22):3007-3022
pubmed: 33103728
Eur Rev Med Pharmacol Sci. 2019 Jun;23(12):5392-5401
pubmed: 31298392
J Biol Chem. 2014 Jan 10;289(2):930-41
pubmed: 24297167
Int J Oncol. 2020 Jan;56(1):18-32
pubmed: 31746420
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):786-91
pubmed: 21187392
Hepatology. 2016 Oct;64(4):1033-48
pubmed: 27338022
Mol Cell Biol. 1990 Jan;10(1):28-36
pubmed: 1688465
Acta Pharmacol Sin. 2017 Jul;38(7):963-976
pubmed: 28414199
Cell Mol Gastroenterol Hepatol. 2020;10(4):699-712
pubmed: 32389640
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3819-23
pubmed: 7731990
Front Biosci (Landmark Ed). 2018 Jan 1;23:614-625
pubmed: 28930564