Patrick Arbuthnot

Affiliations

Wits/SAMRC Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa. Electronic address: patrick.arbuthnot@wits.ac.za.

Publications (23)

In vitro transcribed mRNA for expression of designer nucleases: Advantages as a novel therapeutic for the management of chronic HBV infection.

Advanced drug delivery reviews

Avec: Abdullah Ely , Prashika Singh , Tiffany S Smith , Patrick Arbuthnot

Adenoviral Vectors: Potential as Anti-HBV Vaccines and Therapeutics.

Genes

Avec: Tasneem Farhad , Keila Neves , Patrick Arbuthnot , Mohube Betty Maepa

Self-amplifying RNA vaccines for infectious diseases.

Gene therapy

Avec: Kristie Bloom , Fiona van den Berg , Patrick Arbuthnot

Targeted multi-epitope switching enables straightforward positive/negative selection of CAR T cells.

Gene therapy

Avec: Laura Mosti , Lukas M Langner , Kay O Chmielewski , Patrick Arbuthnot , Jamal Alzubi , Toni Cathomen

Generating DNA Expression Cassettes Encoding Multimeric Artificial MicroRNA Precursors.

Methods in molecular biology (Clifton, N.J.)

Avec: Fiona T van den Berg , Abdullah Ely , Patrick Arbuthnot

Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach.

World journal of gastroenterology

Avec: Prashika Singh , Dylan Kairuz , Patrick Arbuthnot , Kristie Bloom

Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric

Viruses

Avec: Tiffany Smith , Prashika Singh , Kay Ole Chmielewski , Kristie Bloom , Toni Cathomen , Patrick Arbuthnot , Abdullah Ely

Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines.

Pharmaceutics

Avec: Dylan Kairuz , Nazia Samudh , Abdullah Ely , Patrick Arbuthnot , Kristie Bloom

In Vivo Delivery of Cassettes Encoding Anti-HBV Primary MicroRNAs Using an Ancestral Adeno-Associated Viral Vector.

Methods in molecular biology (Clifton, N.J.)

Avec: Njabulo Mnyandu , Patrick Arbuthnot , Mohube Betty Maepa

A convenient method to generate and maintain poly(A)-encoding DNA sequences required for in vitro transcription of mRNA.

BioTechniques

Avec: Patrick Arbuthnot , Abdullah Ely , Kristie Bloom

Diversity of Dysregulated Long Non-Coding RNAs in HBV-Related Hepatocellular Carcinoma.

Frontiers in immunology

Avec: Nazia Samudh , Creanne Shrilall , Patrick Arbuthnot , Kristie Bloom , Abdullah Ely

Hepatitis B Virus Research in South Africa.

Viruses

Avec: Mohube B Maepa , Abdullah Ely , Anna Kramvis , Kristie Bloom , Kubendran Naidoo , Omphile E Simani , Tongai G Maponga , Patrick Arbuthnot

Opportunities and challenges of leveraging COVID-19 vaccine innovation and technologies for developing sustainable vaccine manufacturing capabilities in Africa.

The Lancet. Infectious diseases

Avec: Bavesh D Kana , Patrick Arbuthnot , Benjamin K Botwe , Yahya E Choonara , Fatima Hassan , Hechmi Louzir , Precious Matsoso , Penny L Moore , Apollo Muhairwe , Kubendran Naidoo , Margareth Ndomondo-Sigonda , Shabir A Madhi

Advances with RNAi-Based Therapy for Hepatitis B Virus Infection.

Viruses

Avec: Fiona van den Berg , Shonisani Wendy Limani , Njabulo Mnyandu , Mohube Betty Maepa , Abdullah Ely , Patrick Arbuthnot

Gene and cell therapy in South Africa: Current status and future prospects.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Avec: A Ely , K Bloom , M B Maepa , J N Mahlangu , M S Pepper , P Arbuthnot

Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma

Avec: Abdullah Ely , Kristie Bloom , Mohube Betty Maepa , Patrick Arbuthnot

In Vivo Modelling of Hepatitis B Virus Subgenotype A1 Replication Using Adeno-Associated Viral Vectors.

Viruses

Avec: Shonisani Wendy Limani , Njabulo Mnyandu , Abdullah Ely , Reubina Wadee , Anna Kramvis , Patrick Arbuthnot , Mohube Betty Maepa

Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics.

Virology journal

Avec: Njabulo Mnyandu , Shonisani Wendy Limani , Patrick Arbuthnot , Mohube Betty Maepa

Prospects of viral vector-mediated delivery of sequences encoding anti-HBV designer endonucleases.

Gene therapy

Avec: Ridhwaanah Jacobs , Prashika Singh , Tiffany Smith , Patrick Arbuthnot , Mohube Betty Maepa

Recent developments with advancing gene therapy to treat chronic infection with hepatitis B virus.

Current opinion in HIV and AIDS

Avec: Mohube B Maepa , Ridhwaanah Jacobs , Fiona van den Berg , Patrick Arbuthnot

Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA.

BMC infectious diseases

Avec: Kristie Bloom , Haajira Kaldine , Toni Cathomen , Claudio Mussolino , Abdullah Ely , Patrick Arbuthnot

Advancing mRNA technologies for therapies and vaccines: An African context.

Frontiers in immunology

Avec: Dylan Kairuz , Nazia Samudh , Abdullah Ely , Patrick Arbuthnot , Kristie Bloom

AAV Immunotoxicity: Implications in Anti-HBV Gene Therapy.

Microorganisms

Avec: Ridhwaanah Jacobs , Makafui Dennis Dogbey , Njabulo Mnyandu , Keila Neves , Stefan Barth , Patrick Arbuthnot , Mohube Betty Maepa

Réseau de co-auteurs

Abdullah Ely 12 collaborations

Kristie Bloom 10 collaborations

Mohube Betty Maepa 8 collaborations

Njabulo Mnyandu 5 collaborations

Prashika Singh 4 collaborations

Fiona van den Berg 3 collaborations

Toni Cathomen 3 collaborations

Dylan Kairuz 3 collaborations

Nazia Samudh 3 collaborations

Shonisani Wendy Limani 3 collaborations

Ridhwaanah Jacobs 3 collaborations

Keila Neves 2 collaborations

Tiffany Smith 2 collaborations

Mohube B Maepa 2 collaborations

Anna Kramvis 2 collaborations

Kubendran Naidoo 2 collaborations

Tiffany S Smith 1 collaboration

Tasneem Farhad 1 collaboration

Laura Mosti 1 collaboration

Lukas M Langner 1 collaboration

Kay O Chmielewski 1 collaboration

Jamal Alzubi 1 collaboration

Fiona T van den Berg 1 collaboration

Kay Ole Chmielewski 1 collaboration

Creanne Shrilall 1 collaboration

Omphile E Simani 1 collaboration

Tongai G Maponga 1 collaboration

Bavesh D Kana 1 collaboration

Benjamin K Botwe 1 collaboration

Yahya E Choonara 1 collaboration

Fatima Hassan 1 collaboration

Hechmi Louzir 1 collaboration

Precious Matsoso 1 collaboration

Penny L Moore 1 collaboration

Apollo Muhairwe 1 collaboration

Margareth Ndomondo-Sigonda 1 collaboration

Shabir A Madhi 1 collaboration

A Ely 1 collaboration

K Bloom 1 collaboration

M B Maepa 1 collaboration

J N Mahlangu 1 collaboration

M S Pepper 1 collaboration

P Arbuthnot 1 collaboration

Reubina Wadee 1 collaboration

Haajira Kaldine 1 collaboration

Claudio Mussolino 1 collaboration

Makafui Dennis Dogbey 1 collaboration

Stefan Barth 1 collaboration