Advancing mRNA technologies for therapies and vaccines: An African context.
African vaccine development
lipid nanoparticles
lyophilization
mRNA
mRNA immunogenicity
mRNA modifications
mRNA vaccines
saRNA
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
08
2022
accepted:
10
10
2022
entrez:
10
11
2022
pubmed:
11
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Synthetic mRNA technologies represent a versatile platform that can be used to develop advanced drug products. The remarkable speed with which vaccine development programs designed and manufactured safe and effective COVID-19 vaccines has rekindled interest in mRNA technology, particularly for future pandemic preparedness. Although recent R&D has focused largely on advancing mRNA vaccines and large-scale manufacturing capabilities, the technology has been used to develop various immunotherapies, gene editing strategies, and protein replacement therapies. Within the mRNA technologies toolbox lie several platforms, design principles, and components that can be adapted to modulate immunogenicity, stability,
Identifiants
pubmed: 36353641
doi: 10.3389/fimmu.2022.1018961
pmc: PMC9637871
doi:
Substances chimiques
RNA, Messenger
0
COVID-19 Vaccines
0
Vaccines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1018961Informations de copyright
Copyright © 2022 Kairuz, Samudh, Ely, Arbuthnot and Bloom.
Déclaration de conflit d'intérêts
AE, PA and KB are contracting partners of Afrigen Biologics and Vaccines through the mRNA Hub. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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