Hepatitis B Virus Research in South Africa.
HBV
HBV/HIV co-infection
gene therapy
occult HBV infection
vaccination
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
31 08 2022
31 08 2022
Historique:
received:
29
06
2022
revised:
11
08
2022
accepted:
26
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Despite being vaccine-preventable, hepatitis B virus (HBV) infection remains the seventh leading cause of mortality in the world. In South Africa (SA), over 1.9 million people are chronically infected with HBV, and 70% of all Black chronic carriers are infected with HBV subgenotype A1. The virus remains a significant burden on public health in SA despite the introduction of an infant immunization program implemented in 1995 and the availability of effective treatment for chronic HBV infection. In addition, the high prevalence of HIV infection amplifies HBV replication, predisposes patients to chronicity, and complicates management of the infection. HBV research has made significant progress leading to better understanding of HBV epidemiology and management challenges in the SA context. This has led to recent revision of the national HBV infection management guidelines. Research on developing new vaccines and therapies is underway and progress has been made with designing potentially curative gene therapies against HBV. This review summarizes research carried out in SA on HBV molecular biology, epidemiology, treatment, and vaccination strategies.
Identifiants
pubmed: 36146747
pii: v14091939
doi: 10.3390/v14091939
pmc: PMC9503375
pii:
doi:
Substances chimiques
Hepatitis B Vaccines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Nature. 2018 Dec;564(7734):24-26
pubmed: 30518904
Vaccine. 2015 Aug 26;33(36):4618-22
pubmed: 26163924
Intervirology. 2014;57(3-4):141-50
pubmed: 25034481
J Natl Cancer Inst. 2009 Aug 5;101(15):1066-82
pubmed: 19574418
Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):6-13
pubmed: 9512175
Hepatology. 1999 Mar;29(3):946-53
pubmed: 10051502
S Afr Med J. 2013 May;103(5 Pt 2):337-49
pubmed: 23967497
Lancet. 2015 Oct 17;386(10003):1546-55
pubmed: 26231459
Biotechnol Lett. 2015 Mar;37(3):567-75
pubmed: 25432417
J Infect Dis. 2014 Feb 15;209(4):491-9
pubmed: 24307741
AIDS. 2017 May 15;31(8):1109-1117
pubmed: 28328795
Elife. 2018 Aug 07;7:
pubmed: 30082021
Mol Ther. 2003 Nov;8(5):769-76
pubmed: 14599810
Virus Res. 2017 Jan 2;227:88-95
pubmed: 27720823
Vaccine. 2001 Jul 16;19(28-29):3919-26
pubmed: 11427266
Hepatol Res. 2007 Jul;37(s1):S9-S19
pubmed: 17627641
Infect Genet Evol. 2016 Sep;43:232-8
pubmed: 27245151
Sci Rep. 2021 Apr 14;11(1):8167
pubmed: 33854155
Mol Ther. 2007 Mar;15(3):534-41
pubmed: 17213835
J Gen Virol. 1997 Jul;78 ( Pt 7):1719-29
pubmed: 9225049
Lancet Gastroenterol Hepatol. 2022 Aug;7(8):724-735
pubmed: 35576953
J Gen Virol. 2016 Jul;97(7):1615-1624
pubmed: 27031988
BMC Public Health. 2019 Jun 26;19(1):829
pubmed: 31242901
Curr Opin HIV AIDS. 2020 May;15(3):185-192
pubmed: 32141888
J Med Virol. 2009 Mar;81(3):406-12
pubmed: 19152393
Clin Ther. 2018 Aug;40(8):1255-1267
pubmed: 29983265
PLoS One. 2012;7(10):e48108
pubmed: 23144732
Nat Rev Immunol. 2021 Oct;21(10):626-636
pubmed: 34373623
Health Res Policy Syst. 2021 Jan 6;19(1):2
pubmed: 33407574
Viruses. 2021 Jul 12;13(7):
pubmed: 34372550
Microsc Res Tech. 2020 May;83(5):499-506
pubmed: 31926041
J Clin Virol. 2006 Jan;35(1):14-20
pubmed: 15916918
NPJ Vaccines. 2021 Aug 5;6(1):97
pubmed: 34354082
J Viral Hepat. 2012 Oct;19(10):716-23
pubmed: 22967103
Int J Infect Dis. 2009 Jul;13(4):488-92
pubmed: 19081280
J Immunol. 2016 Apr 1;196(7):3079-87
pubmed: 26936879
FEBS Lett. 2003 May 22;543(1-3):51-4
pubmed: 12753904
Viruses. 2020 Jun 11;12(6):
pubmed: 32545313
J Viral Hepat. 2020 Mar;27(3):294-315
pubmed: 31603999
Hepatol Res. 2008 Jun;38(6):580-92
pubmed: 18201182
J Hepatol. 1998 Jan;28(1):132-41
pubmed: 9537850
PLoS One. 2012;7(3):e32789
pubmed: 22479339
Infect Genet Evol. 2013 Dec;20:103-10
pubmed: 23978387
Cells. 2019 Nov 24;8(12):
pubmed: 31771261
Front Microbiol. 2018 Oct 24;9:2521
pubmed: 30405578
Virus Res. 2012 Jan;163(1):334-40
pubmed: 22100339
World J Gastroenterol. 2005 Mar 7;11(9):1297-302
pubmed: 15761967
J Formos Med Assoc. 2011 Apr;110(4):239-46
pubmed: 21540006
Int J Mol Sci. 2022 Jan 27;23(3):
pubmed: 35163414
J Infect Dis. 2021 Sep 30;224(12 Suppl 2):S343-S351
pubmed: 34590138
Pharmaceutics. 2021 Feb 24;13(3):
pubmed: 33668320
J Med Virol. 2009 Jun;81(6):996-1001
pubmed: 19382250
Wellcome Open Res. 2020 Jun 1;5:113
pubmed: 33274299
Virology. 2020 Jan 15;540:97-103
pubmed: 31765921
J Med Virol. 2014 Jun;86(6):918-24
pubmed: 24615635
Nat Biotechnol. 2005 Aug;23(8):1002-7
pubmed: 16041363
Mem Inst Oswaldo Cruz. 2020 Sep 23;115:e200006
pubmed: 32997000
Mol Ther. 2013 Oct;21(10):1889-97
pubmed: 23883864
Hepatology. 2005 Jun;41(6):1349-56
pubmed: 15880588
BMC Infect Dis. 2020 Jun 5;20(1):395
pubmed: 32503443
Intervirology. 2016;59(1):48-59
pubmed: 27553619
J Viral Hepat. 2008 Feb;15(2):103-7
pubmed: 18184192
J Med Virol. 2005 Apr;75(4):513-21
pubmed: 15714494
J Clin Virol. 2015 Feb;63:12-7
pubmed: 25600597
Protein Eng. 1997 Jan;10(1):1-6
pubmed: 9051728
Bioorg Med Chem. 2013 Oct 15;21(20):6145-55
pubmed: 23743442
PLoS One. 2012;7(9):e46345
pubmed: 23029487
J Gen Virol. 2008 Nov;89(Pt 11):2882-2890
pubmed: 18931087
Int J Infect Dis. 2012 Apr;16(4):e268-72
pubmed: 22305987
Hepatology. 1997 Jan;25(1):235-40
pubmed: 8985297
J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):174-82
pubmed: 23892239
Gastroenterology. 2003 Nov;125(5):1370-8
pubmed: 14598253
Hepatol Res. 2007 Jul;37(s1):S27-32
pubmed: 17627631
PLoS One. 2017 Jul 21;12(7):e0181267
pubmed: 28732085
Methods Mol Biol. 2020;2115:171-183
pubmed: 32006401
J Viral Hepat. 2020 Jun;27(6):560-567
pubmed: 31800145
J Hepatol. 2012 Oct;57(4):720-9
pubmed: 22634131
Mol Pharm. 2009 May-Jun;6(3):706-17
pubmed: 19159285
Vaccine. 2016 Jul 19;34(33):3835-9
pubmed: 27265453
J Control Release. 2015 Jul 10;209:198-206
pubmed: 25937322
Arch Virol. 2020 Aug;165(8):1815-1825
pubmed: 32504396
J Med Virol. 2009 Jul;81(7):1177-83
pubmed: 19475606
J Infect. 2020 Jul;81(1):121-130
pubmed: 32360882
Intervirology. 2004;47(6):289-309
pubmed: 15564741
Biomed Res Int. 2014;2014:718743
pubmed: 25003129
Liver Int. 2005 Apr;25(2):201-13
pubmed: 15780040
Vaccine. 2013 Nov 12;31(47):5579-84
pubmed: 23973500
Infect Genet Evol. 2014 Jun;24:68-75
pubmed: 24642137
BMC Infect Dis. 2018 May 8;18(1):214
pubmed: 29739341
PLoS Med. 2020 Apr 21;17(4):e1003068
pubmed: 32315297
J Viral Hepat. 2011 Oct;18(10):721-9
pubmed: 21914087
JAMA. 1984 Jul 13;252(2):252-7
pubmed: 6374187
BMC Infect Dis. 2020 Nov 16;20(1):847
pubmed: 33198649
Gastroenterology. 2014 Apr;146(4):1070-83
pubmed: 24361467
Future Oncol. 2021 May;17(13):1577-1580
pubmed: 33590770
Gastroenterology. 2003 Jul;125(1):9-18
pubmed: 12851866
World J Gastroenterol. 2021 Jun 21;27(23):3182-3207
pubmed: 34163105
J Med Virol. 2007 Nov;79(11):1650-4
pubmed: 17854040
J Hepatol. 1994 Mar;20(3):398-404
pubmed: 8014453
Mol Ther Nucleic Acids. 2017 Jun 16;7:190-199
pubmed: 28624194
Clin Gastroenterol Hepatol. 2016 Sep;14(9):1324-30
pubmed: 27155556
J Gen Virol. 2017 Jun;98(6):1422-1433
pubmed: 28678685
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Biochem Biophys Res Commun. 2016 Sep 30;478(4):1563-8
pubmed: 27590580
Vaccine. 1990 Mar;8 Suppl:S69-73; discussion S79-80
pubmed: 2139287
Gene Ther. 2015 Feb;22(2):163-71
pubmed: 25338920
Am J Med Sci. 1975 Sep-Oct;270(2):395-9
pubmed: 828832
Nucleic Acids Res. 2009 Jul;37(13):e91
pubmed: 19474340
Z Naturforsch C J Biosci. 2017 Jul 14;72(7-8):293-301
pubmed: 28063265
Viruses. 2021 Nov 09;13(11):
pubmed: 34835053
Antivir Ther. 2013;18(3 Pt B):513-21
pubmed: 23792935
J Hepatol. 2019 Aug;71(2):274-280
pubmed: 30965070
Genes (Basel). 2018 Aug 21;9(9):
pubmed: 30134551
Lancet Infect Dis. 2002 Jul;2(7):395-403
pubmed: 12127351
World J Hepatol. 2010 Feb 27;2(2):65-73
pubmed: 21160975
AIDS. 2015 Jun 19;29(10):1173-82
pubmed: 26035319
Chem Biol Drug Des. 2012 Nov;80(5):647-56
pubmed: 22783887
Gastroenterology. 2007 Nov;133(5):1466-74
pubmed: 17915220
Virol J. 2021 Dec 13;18(1):247
pubmed: 34903258
J Infect. 1986 Jul;13 Suppl A:3-9
pubmed: 2427590
J Gen Virol. 2002 Apr;83(Pt 4):835-839
pubmed: 11907333
Viruses. 2022 Apr 10;14(4):
pubmed: 35458518
S Afr Med J. 2018 Aug 08;108(8b):17-21
pubmed: 30182908
Hepatology. 2006 Oct;44(4):915-24
pubmed: 17006908
World J Gastroenterol. 2021 Sep 28;27(36):6025-6038
pubmed: 34629817
Sci Rep. 2017 Aug 7;7(1):7401
pubmed: 28785016
Clin Microbiol Rev. 2020 Feb 26;33(2):
pubmed: 32102898
Antivir Ther. 2014;19(4):363-73
pubmed: 24296696
Vaccine. 2019 Jan 7;37(2):223-225
pubmed: 28743487
NPJ Vaccines. 2021 Dec 20;6(1):157
pubmed: 34930928
Am J Med Sci. 1975 Sep-Oct;270(2):401-4
pubmed: 828833
Mol Ther. 2006 Feb;13(2):411-21
pubmed: 16337206
J Clin Virol. 2020 Aug;129:104548
pubmed: 32663786
Hum Gene Ther. 2008 Nov;19(11):1325-31
pubmed: 19848584
J Gen Virol. 2004 May;85(Pt 5):1211-1220
pubmed: 15105537
Epidemiol Rev. 2006;28:112-25
pubmed: 16754644
J Infect Dis. 2006 Sep 1;194(5):594-9
pubmed: 16897657
J Acquir Immune Defic Syndr. 2012 Aug 1;60(4):e111-2
pubmed: 22772348
Clin Microbiol Rev. 2012 Jan;25(1):142-63
pubmed: 22232374
Expert Rev Vaccines. 2017 Aug;16(8):811-832
pubmed: 28573913
BMC Infect Dis. 2019 Sep 12;19(1):802
pubmed: 31510934
Mol Ther. 2008 Jun;16(6):1105-12
pubmed: 18431360
BMC Gastroenterol. 2020 Jul 13;20(1):226
pubmed: 32660431
Viruses. 2022 Jan 03;14(1):
pubmed: 35062286
Transfusion. 2012 Apr;52(4):880-92
pubmed: 21981386
J Med Virol. 2019 May;91(5):758-764
pubmed: 30515847
Clin Infect Dis. 2013 May;56(9):e87-94
pubmed: 23315316
Transfusion. 2003 Jun;43(6):788-98
pubmed: 12757531
Vaccine. 2005 Mar 31;23(19):2409-23
pubmed: 15752827
Expert Rev Gastroenterol Hepatol. 2018 Jun;12(6):537-546
pubmed: 29737218
Microrna. 2012;1(1):19-25
pubmed: 25048086
Hepatology. 2003 Oct;38(4):842-50
pubmed: 14512871
Pediatr Infect Dis J. 2019 Mar;38(3):e51-e53
pubmed: 29601455
Science. 2002 Apr 19;296(5567):550-3
pubmed: 11910072
South Afr J HIV Med. 2018 Mar 27;19(1):737
pubmed: 29707384
PLoS One. 2012;7(10):e45750
pubmed: 23049685
J Virol. 2009 Oct;83(20):10538-47
pubmed: 19640977
BMC Cancer. 2018 Aug 7;18(1):798
pubmed: 30086727
PLoS One. 2020 Oct 8;15(10):e0240375
pubmed: 33031453
J Virol Methods. 2014 Jul;203:54-64
pubmed: 24681050
Hepatology. 2004 Sep;40(3):747-55
pubmed: 15349915
Semin Immunopathol. 2013 Jan;35(1):39-52
pubmed: 22829332
World J Gastroenterol. 2013 Dec 28;19(48):9294-306
pubmed: 24409056
J Med Virol. 2015 Mar;87(3):388-400
pubmed: 25164924
J Clin Invest. 2021 Mar 1;131(5):
pubmed: 33529172
J Med Virol. 2008 Jan;80(1):27-46
pubmed: 18041043
Drugs. 2003;63(10):1021-51
pubmed: 12699402
Nature. 2006 May 25;441(7092):537-41
pubmed: 16724069
Artif DNA PNA XNA. 2010 Jul;1(1):17-26
pubmed: 21687523