Theta-Defensins to Counter COVID-19 as Furin Inhibitors:
Animals
Antimicrobial Peptides
/ chemistry
Antiviral Agents
/ pharmacology
COVID-19
/ metabolism
Catalytic Domain
Cell Membrane
/ virology
Computer Simulation
Data Mining
Defensins
/ pharmacology
Drug Design
Furin
/ antagonists & inhibitors
Humans
Inflammation
Models, Molecular
Molecular Docking Simulation
Peptides
/ chemistry
Software
Spike Glycoprotein, Coronavirus
Static Electricity
COVID-19 Drug Treatment
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
09
2021
revised:
28
12
2021
accepted:
21
01
2022
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
1
3
2022
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was characterized as a pandemic by the World Health Organization (WHO) in Dec. 2019. SARS-CoV-2 binds to the cell membrane through spike proteins on its surface and infects the cell. Furin, a host-cell enzyme, possesses a binding site for the spike protein. Thus, molecules that block furin could potentially be a therapeutic solution. Defensins are antimicrobial peptides that can hypothetically inhibit furin because of their arginine-rich structure. Theta-defensins, a subclass of defensins, have attracted attention as drug candidates due to their small size, unique structure, and involvement in several defense mechanisms. Theta-defensins could be a potential treatment for COVID-19 through furin inhibition and an anti-inflammatory mechanism. Note that inflammatory events are a significant and deadly condition that could happen at the later stages of COVID-19 infection. Here, the potential of theta-defensins against SARS-CoV-2 infection was investigated through
Identifiants
pubmed: 35154362
doi: 10.1155/2022/9735626
pmc: PMC8829439
doi:
Substances chimiques
Antimicrobial Peptides
0
Antiviral Agents
0
Defensins
0
Peptides
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
theta-defensin
0
FURIN protein, human
EC 3.4.21.75
Furin
EC 3.4.21.75
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9735626Informations de copyright
Copyright © 2022 Manica Negahdaripour et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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