HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19.
COVID-19
HLA
SARS-CoV-2
T-cell immunity
immunogenetics
vaccine
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
26
01
2022
received:
11
11
2021
accepted:
28
01
2022
pubmed:
15
2
2022
medline:
20
4
2022
entrez:
14
2
2022
Statut:
ppublish
Résumé
SARS-CoV-2 infection results in different outcomes ranging from asymptomatic infection to mild or severe disease and death. Reasons for this diversity of outcome include differences in challenge dose, age, gender, comorbidity and host genomic variation. Human leukocyte antigen (HLA) polymorphisms may influence immune response and disease outcome. We investigated the association of HLAII alleles with case definition symptomatic COVID-19, virus-specific antibody and T-cell immunity. A total of 1364 UK healthcare workers (HCWs) were recruited during the first UK SARS-CoV-2 wave and analysed longitudinally, encompassing regular PCR screening for infection, symptom reporting, imputation of HLAII genotype and analysis for antibody and T-cell responses to nucleoprotein (N) and spike (S). Of 272 (20%) HCW who seroconverted, the presence of HLA-DRB1*13:02 was associated with a 6·7-fold increased risk of case definition symptomatic COVID-19. In terms of immune responsiveness, HLA-DRB1*15:02 was associated with lower nucleocapsid T-cell responses. There was no association between DRB1 alleles and anti-spike antibody titres after two COVID vaccine doses. However, HLA DRB1*15:01 was associated with increased spike T-cell responses following both first and second dose vaccination. Trial registration: NCT04318314 and ISRCTN15677965.
Identifiants
pubmed: 35156709
doi: 10.1111/imm.13450
pmc: PMC9111350
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
HLA-DRB1 Chains
0
Histocompatibility Antigens Class I
0
Banques de données
ClinicalTrials.gov
['NCT04318314']
Types de publication
Clinical Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
68-77Subventions
Organisme : Medical Research Council
ID : MR/S019553/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W020610/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/19/35/34374
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V027883/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20060
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/CRTF/21/24128
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R02622X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207511/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V036939/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/21/33447
Pays : United Kingdom
Investigateurs
Hakam Abbass
(H)
Aderonke Abiodun
(A)
Mashael Alfarih
(M)
Zoe Alldis
(Z)
Daniel M Altmann
(DM)
Oliver E Amin
(OE)
Mervyn Andiapen
(M)
Jessica Artico
(J)
João B Augusto
(JB)
Georgiana L Baca
(GL)
Sasha N L Bailey
(SNL)
Anish N Bhuva
(AN)
Alex Boulter
(A)
Ruth Bowles
(R)
Rosemary J Boyton
(RJ)
Olivia V Bracken
(OV)
Ben O'Brien
(B)
Tim Brooks
(T)
Natalie Bullock
(N)
David K Butler
(DK)
Gabriella Captur
(G)
Nicola Champion
(N)
Carmen Chan
(C)
Aneesh Chandran
(A)
David Collier
(D)
Jorge Couto de Sousa
(JC)
Xose Couto-Parada
(X)
Teresa Cutino-Moguel
(T)
Rhodri H Davies
(RH)
Brooke Douglas
(B)
Cecilia Genova
(C)
Keenan Dieobi-Anene
(K)
Mariana O Diniz
(MO)
Anaya Ellis
(A)
Karen Feehan
(K)
Malcolm Finlay
(M)
Marianna Fontana
(M)
Nasim Forooghi
(N)
Celia Gaier
(C)
Joseph M Gibbons
(JM)
Derek Gilroy
(D)
Matt Hamblin
(M)
Gabrielle Harker
(G)
Jacqueline Hewson
(J)
Lauren M Hickling
(LM)
Aroon D Hingorani
(AD)
Lee Howes
(L)
Alun Hughes
(A)
Gemma Hughes
(G)
Rebecca Hughes
(R)
Ivie Itua
(I)
Victor Jardim
(V)
Wing-Yiu Jason Lee
(WJ)
Melaniepetra Jensen
(M)
Jessica Jones
(J)
Meleri Jones
(M)
George Joy
(G)
Vikas Kapil
(V)
Hibba Kurdi
(H)
Jonathan Lambourne
(J)
Kai-Min Lin
(KM)
Sarah Louth
(S)
Mala K Maini
(MK)
Vineela Mandadapu
(V)
Charlotte Manisty
(C)
Áine McKnight
(Á)
Katia Menacho
(K)
Celina Mfuko
(C)
Oliver Mitchelmore
(O)
Christopher Moon
(C)
James C Moon
(JC)
Diana C Muñoz-Sandoval
(DC)
Sam M Murray
(SM)
Mahdad Noursadeghi
(M)
Ashley Otter
(A)
Corinna Pade
(C)
Susana Palma
(S)
Ruth Parker
(R)
Kush Patel
(K)
Babita Pawarova
(B)
Steffen E Petersen
(SE)
Brian Piniera
(B)
Franziska P Pieper
(FP)
Daniel Pope
(D)
Mary Prossora
(M)
Lisa Rannigan
(L)
Alicja Rapala
(A)
Catherine J Reynolds
(CJ)
Amy Richards
(A)
Matthew Robathan
(M)
Joshua Rosenheim
(J)
Genine Sambile
(G)
Nathalie M Schmidt
(NM)
Amanda Semper
(A)
Andreas Seraphim
(A)
Mihaela Simion
(M)
Angelique Smit
(A)
Michelle Sugimoto
(M)
Leo Swadling
(L)
Stephen Taylor
(S)
Nigel Temperton
(N)
Stephen Thomas
(S)
George D Thornton
(GD)
Thomas A Treibel
(TA)
Art Tucker
(A)
Jessry Veerapen
(J)
Mohit Vijayakumar
(M)
Sophie Welch
(S)
Theresa Wodehouse
(T)
Lucinda Wynne
(L)
Dan Zahedi
(D)
Daniel M Altmann
(DM)
Rosemary J Boyton
(RJ)
Tim Brooks
(T)
Benjamin Chain
(B)
Mala K Maini
(MK)
Charlotte Manisty
(C)
Áine McKnight
(Á)
James C Moon
(JC)
Mahdad Noursadeghi
(M)
Thomas A Treibel
(TA)
Guruprasad P Aithal
(GP)
Waheed Ashraf
(W)
Stuart Astbury
(S)
Jonathan K Ball
(JK)
Joseph G Chappell
(JG)
Simon Craxford
(S)
Lola M L Cusin
(LML)
Joshua D Duncan
(JD)
Adeel Ikram
(A)
William L Irving
(WL)
Hannah J Jackson
(HJ)
Anthony Kelly
(A)
Melanie Lingaya
(M)
Ben A Marson
(BA)
Jayne Newham
(J)
Jessica Nightingale
(J)
Alan Norrish
(A)
Barbara Nowicka
(B)
Benjamin J Ollivere
(BJ)
Alexander W Tarr
(AW)
Patrick J Tighe
(PJ)
Theocharis Tsoleridis
(T)
Richard A Urbanowicz
(RA)
Ana M Valdes
(AM)
Amrita Vijay
(A)
Informations de copyright
© 2022 The Authors. Immunology published by John Wiley & Sons Ltd.
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