Whole Genome Sequencing Reveals Independent Clonal Origin of Bilateral Testicular Germ Cell Tumors in 2 Patients with Pure Seminoma.

Humans Male Neoplasms, Germ Cell and Embryonal / genetics Seminoma / genetics Testicular Neoplasms / genetics Whole Genome Sequencing

Journal

Urology
ISSN: 1527-9995
Titre abrégé: Urology
Pays: United States
ID NLM: 0366151

Informations de publication

Date de publication:
07 2022
Historique:
received: 14 05 2021
revised: 22 12 2021
accepted: 13 01 2022
pubmed: 15 2 2022
medline: 20 7 2022
entrez: 14 2 2022
Statut: ppublish

Résumé

The pathophysiology of bilateral testicular germ cell tumors (TGCT) is poorly understood. It is unclear if they develop independently, arise from common germline genetic changes, or metastasize from one gonad to the other. We determined the underlying genomic alterations in two cases of bilateral TGCTs with pure seminoma using whole genome sequencing. Large chromosomal aberrations and KIT amplification were identified, but there were no shared single nucleotide variants or structural chromosomal rearrangements in paired TGCTs, suggesting they develop independently. The biological behavior of bilateral TGCTs may be distinct and the staging and prognostic evaluation of each tumor should be performed independently.

Identifiants

DOI: 10.1016/j.urology.2022.01.025 PMID: 35157907
pubmed: 35157907
pii: S0090-4295(22)00074-7
doi: 10.1016/j.urology.2022.01.025
pii:
doi:

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

184-186

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Michael J Biles (MJ)

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

Michael C Haffner (MC)

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Pathology, University of Washington, Seattle, WA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Brian Hanratty (B)

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA.

Phillip M Pierorazio (PM)

Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Whole Genome Sequencing Reveals Independent...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs embryonnaires et germinales › Whole Genome Sequencing Reveals Independent...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs embryonnaires et germinales › Germinome › Séminome › Whole Genome Sequencing Reveals Independent...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies testiculaires › Tumeurs du testicule › Whole Genome Sequencing Reveals Independent...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Whole Genome Sequencing Reveals Independent...