Oncogenic Events Dictate the Types and Locations of Gynecological Malignancies Originating from
Keratin 8 (K8)
Müllerian-derived epithelial cells
cellular origin
endometrial cells
fallopian tube epithelial (FTE) cells
mesothelial cells
mouse modeling
ovarian cancer
ovarian surface epithelial (OSE) cells
uterine cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Feb 2022
08 Feb 2022
Historique:
received:
23
12
2021
revised:
02
02
2022
accepted:
05
02
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
16
2
2022
Statut:
epublish
Résumé
Ovarian and uterine cancers are the most prevalent types of gynecological malignancies originating from mesothelial and/or Müllerian-derived epithelial cells. Recent genomic studies have identified common mutations in them that affect signaling pathways such as p53, PTEN/PI3K, RAS, and WNT pathways. However, how these mutations and their corresponding deregulated pathways affect gynecological cancer development from their cells-of-origin remains largely elusive. To address this, we performed the intrabursal injection of Cre-expressing adenovirus under the control of
Identifiants
pubmed: 35159108
pii: cancers14030841
doi: 10.3390/cancers14030841
pmc: PMC8834519
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : United States Department of Defense
ID : W81XWH-14-1-0280
Organisme : Harvard Stem Cell Institute
ID : DP-0164-17-00
Organisme : Brigham and Women's Hospital
ID : Sundry Fund
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