SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration.
Animals
Armadillo Domain Proteins
/ genetics
Cells, Cultured
Cytoskeletal Proteins
/ genetics
Disease Models, Animal
Energy Metabolism
Female
Fibroblasts
/ cytology
Gene Knockout Techniques
Male
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Oxygen Consumption
Primary Cell Culture
Retinal Degeneration
/ chemically induced
Retinal Ganglion Cells
/ physiology
Rotenone
/ adverse effects
NAD+
NADase
axon degeneration
retinal degeneration
sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jan 2022
30 Jan 2022
Historique:
received:
27
10
2021
revised:
21
01
2022
accepted:
26
01
2022
entrez:
15
2
2022
pubmed:
16
2
2022
medline:
15
3
2022
Statut:
epublish
Résumé
The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a gene-independent approach. Mitochondrial dysfunction and axon degeneration are common features of many neurodegenerative conditions including retinal degenerations. Here we explore the neuroprotective effect afforded by the absence of sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1), a prodegenerative NADase, in a rotenone-induced mouse model of retinal ganglion cell loss and visual dysfunction.
Identifiants
pubmed: 35163535
pii: ijms23031606
doi: 10.3390/ijms23031606
pmc: PMC8835928
pii:
doi:
Substances chimiques
Armadillo Domain Proteins
0
Cytoskeletal Proteins
0
SARM1 protein, mouse
0
Rotenone
03L9OT429T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Science Foundation Ireland
ID : 16/IA/4452
Pays : Ireland
Organisme : Science Foundation Ireland
ID : 16/IA/4376
Pays : Ireland
Organisme : Irish Research Council
ID : GOIPG/2017/1631
Organisme : Health Research Board of Ireland
ID : HRAPOR-2015-1140
Organisme : Fighting Blindness Ireland - Health Research Board of Ireland - Health Research Charities Ireland
ID : MRCG-2012-4
Organisme : Fighting Blindness Ireland - Health Research Board of Ireland - Health Research Charities Ireland
ID : MRCG-2016-14
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