Use of speckle tracking echocardiography to detect late anthracycline-induced cardiotoxicity in childhood cancer: A prospective controlled cross-sectional study.
Adolescent
Anthracyclines
/ adverse effects
Antibiotics, Antineoplastic
/ adverse effects
Cardiotoxicity
/ diagnostic imaging
Child
Cross-Sectional Studies
Echocardiography
Female
Humans
Male
Neoplasms
/ diagnostic imaging
Prospective Studies
Ventricular Dysfunction, Left
/ chemically induced
Ventricular Function, Left
2D strain
Cardiomyopathy
Chemotherapy
Echocardiography
Heart failure
Paediatrics
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 May 2022
01 May 2022
Historique:
received:
04
10
2021
revised:
09
01
2022
accepted:
10
02
2022
pubmed:
16
2
2022
medline:
15
4
2022
entrez:
15
2
2022
Statut:
ppublish
Résumé
This study aimed to detect late sub-clinical patterns of cardiac dysfunction using speckle tracking echocardiography (STE) in children with cancer remission more than 12 months after the end of anthracycline treatment. This prospective controlled study enrolled 196 children, 98 of which had been treated with anthracyclines (mean age 10.8 ± 3.6 years; 51% female) and 98 were age- and gender-matched healthy subjects in a 1:1 case-control design. Conventional echocardiographic variables were collected for left ventricle (LV) and right ventricle (RV). STE analyses were performed in the LV longitudinal, radial, and circumferential displacements and in the RV free wall longitudinal displacement. The association between LV global longitudinal strain (GLS) and the main clinical and biological parameters was evaluated. After a mean time interval of 5.1 ± 3.2 years since the end of chemotherapy (mean cumulative anthracycline dose of 192 ± 96 mg/m The existence of a modified LV strain despite normal LV function in children treated with anthracyclines represents an important perspective for cardiomyopathy surveillance in childhood cancer survivors. Clinical Trial Registration -ClinicalTrials.gov Identifier: NCT02893787.
Sections du résumé
BACKGROUND
BACKGROUND
This study aimed to detect late sub-clinical patterns of cardiac dysfunction using speckle tracking echocardiography (STE) in children with cancer remission more than 12 months after the end of anthracycline treatment.
METHODS
METHODS
This prospective controlled study enrolled 196 children, 98 of which had been treated with anthracyclines (mean age 10.8 ± 3.6 years; 51% female) and 98 were age- and gender-matched healthy subjects in a 1:1 case-control design. Conventional echocardiographic variables were collected for left ventricle (LV) and right ventricle (RV). STE analyses were performed in the LV longitudinal, radial, and circumferential displacements and in the RV free wall longitudinal displacement. The association between LV global longitudinal strain (GLS) and the main clinical and biological parameters was evaluated.
RESULTS
RESULTS
After a mean time interval of 5.1 ± 3.2 years since the end of chemotherapy (mean cumulative anthracycline dose of 192 ± 96 mg/m
CONCLUSIONS
CONCLUSIONS
The existence of a modified LV strain despite normal LV function in children treated with anthracyclines represents an important perspective for cardiomyopathy surveillance in childhood cancer survivors. Clinical Trial Registration -ClinicalTrials.gov Identifier: NCT02893787.
Identifiants
pubmed: 35167907
pii: S0167-5273(22)00247-9
doi: 10.1016/j.ijcard.2022.02.012
pii:
doi:
Substances chimiques
Anthracyclines
0
Antibiotics, Antineoplastic
0
Banques de données
ClinicalTrials.gov
['NCT02893787']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-83Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.