DREAMTIME NMR Spectroscopy: Targeted Multi-Compound Selection with Improved Detection Limits.
In Vivo
Metabolism
Multiple Selection
Sensitivity Improvement
Targeted NMR
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
02 05 2022
02 05 2022
Historique:
received:
27
07
2021
pubmed:
17
2
2022
medline:
27
4
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
NMR/MRI are critical tools for studying molecular structure and interactions but suffer from relatively low sensitivity and spectral overlap. Here, a Nuclear Magnetic Resonance (NMR) approach, termed DREAMTIME, is introduced that provides "a molecular window" inside complex systems, capable of showing only what the user desires, with complete molecular specificity. The user chooses a list of molecules of interest, and the approach detects only those targets while all other molecules are invisible. The approach is demonstrated in whole human blood and urine, small living aquatic organisms in 1D/2D NMR, and MRI. Finally, as proof-of-concept, once overlap is removed via DREAMTIME, a novel "multi-focusing" approach can be used to increase sensitivity. In human blood and urine, sensitivity increases of 7-12 fold over standard
Identifiants
pubmed: 35170183
doi: 10.1002/anie.202110044
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202110044Informations de copyright
© 2022 Wiley-VCH GmbH.
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