Plasma pharmacokinetics, pulmonary disposition, and safety of subcutaneous gamithromycin in alpacas.
Alpaca
camelid
gamithromycin
pharmacokinetics
pulmonary
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
27
01
2022
received:
20
08
2021
accepted:
30
01
2022
pubmed:
17
2
2022
medline:
11
5
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
The study objective was to determine the disposition of gamithromycin in plasma, peripheral blood polymorphonuclear cells (PMNs), pulmonary epithelial lining fluid (PELF), and bronchoalveolar lavage (BAL) cells in alpacas. A single subcutaneous injection of gamithromycin (6.6 mg/kg) was administered to six healthy adult alpacas. At various time points after administration, gamithromycin concentrations were analyzed via LC-MS/MS in plasma, PMNs, PELF, and BAL cells until Day 14 post-injection. Plasma gamithromycin concentrations were measured in all six alpacas; the remaining three body compartments were analyzed in four alpacas. Gamithromycin rapidly concentrated in blood PMNs, BAL cells, and PELF. Shorter T
Substances chimiques
Anti-Bacterial Agents
0
Macrolides
0
gamithromycin
ZE856183S0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-290Subventions
Organisme : Northwest Camelid Foundation
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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