Structurally Related Liposomes Containing
antibacterial activity
l-prolinol derivatives
liposomes
structure−activity relation
synergistic effect
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
07 03 2022
07 03 2022
Historique:
pubmed:
17
2
2022
medline:
12
4
2022
entrez:
16
2
2022
Statut:
ppublish
Résumé
Although liposomes are largely investigated as drug delivery systems, they can also exert a pharmacological activity if devoid of an active principle as a function of their composition. Specifically, charged liposomes can electrostatically interact with bacterial cells and, in some cases, induce bacterial cell death. Moreover, they also show a high affinity toward bacterial biofilms. We investigated the physicochemical and antimicrobial properties of liposomes formulated with a natural phospholipid and four synthetic l-prolinol-derived surfactants at 9/1 and 8/2 molar ratios. The synthetic components differ in the nature of the polar headgroup (quaternary ammonium salt or
Identifiants
pubmed: 35170971
doi: 10.1021/acs.molpharmaceut.1c00609
pmc: PMC8905576
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Liposomes
0
Oxides
0
Surface-Active Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
788-797Références
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