Upregulation of Checkpoint Ligand Programmed Death-Ligand 1 in Patients with Paroxysmal Nocturnal Hemoglobinuria Explained by Proximal Complement Activation.
B7-H1 Antigen
/ blood
CD55 Antigens
/ genetics
CD59 Antigens
/ genetics
Complement Activation
/ immunology
Complement C3
/ antagonists & inhibitors
Complement C5
/ antagonists & inhibitors
Granulocytes
/ metabolism
Hematopoietic Stem Cells
/ cytology
Hemoglobinuria, Paroxysmal
/ immunology
Humans
Immune Evasion
/ immunology
Membrane Proteins
/ genetics
Monocytes
/ metabolism
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
13
01
2021
accepted:
17
12
2021
pubmed:
18
2
2022
medline:
8
3
2022
entrez:
17
2
2022
Statut:
ppublish
Résumé
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic disease driven by impaired complement regulation. Mutations in genes encoding the enzymes that build the GPI anchors are causative, with somatic mutations in the
Identifiants
pubmed: 35173033
pii: jimmunol.2100031
doi: 10.4049/jimmunol.2100031
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
CD55 Antigens
0
CD59 Antigens
0
Complement C3
0
Complement C5
0
Membrane Proteins
0
phosphatidylinositol glycan-class A protein
0
CD59 protein, human
101754-01-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1248-1258Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.