Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium.

The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and Parkinson's disease dementia (PDD). The meeting featured eight internationally known scientists from Europe and the United States and attracted over 200 scientists and physicians from academic centers, the National Institutes of Health, and the pharmaceutical industry. Methods for confirming and quantifying the presence of Lewy body and Alzheimer's pathology and novel biomarkers were discussed.

Informations de copyright

Copyright © 2022 Scott, Arnold, Beach, Gibbons, Kanthasamy, Lebovitz, Lemstra, Shaw, Teunissen, Zetterberg, Taylor, Graham, Boeve, Gomperts, Graff-Radford, Moussa, Poston, Rosenthal, Sabbagh, Walsh, Weber, Armstrong, Bang, Bozoki, Domoto-Reilly, Duda, Fleisher, Galasko, Galvin, Goldman, Holden, Honig, Huddleston, Leverenz, Litvan, Manning, Marder, Pantelyat, Pelak, Scharre, Sha, Shill, Mari, Quinn and Irwin.

Déclaration de conflit d'intérêts

TB has conducted consultation for a peripheral synuclein assay and speakers honorarium from Roche Diagnostics. RL is employed full time by Amprion, serves on Amprion's Board, and is a shareholder. CT research is supported by the European Commission (Marie Curie International Training Network, grant agreement No 860197 (MIRIADE), and JPND), Health Holland, the Dutch Research Council (ZonMW), Alzheimer Drug Discovery Foundation, the Selfridges Group Foundation, Alzheimer Netherlands, Alzheimer Association. CT is the recipient of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and Health Holland, Topsector Life Sciences & Health (PPP allowance; #LSHM20106). More than 30 partners participate in ABOARD. ABOARD also receives funding from Edwin Bouw Fonds and Gieskes Strijbisfonds. IV is appointed on a research grant by Alzheimer Nederland (NL 17004). CT has a collaboration contract with ADx Neurosciences, Quanterix, and Eli Lilly, who performed contract research or received grants from AC Immune, Axon Neurosciences, Biogen, Brainstorm Therapeutics, Celgene, EIP Pharma, Eisai, PeopleBio, Roche, Toyama, Vivoryon. CT serves on editorial boards of Medidact Neurologie/Springer, Alzheimer Research and Therapy, Neurology: Neuroimmunology and Neuroinflammation, and is editor of a Neuromethods book by Springer. HZ has served at scientific advisory boards and/or as a consultant for Abbvie, Alector, Eisai, Denali, Roche Diagnostics, Wave, Samumed, Siemens Healthineers, Pinteon Therapeutics, Nervgen, AZTherapies, CogRx, and Red Abbey Labs has given lectures in symposia sponsored by Cellectricon, Fujirebio, Alzecure and Biogen, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (all outside submitted work). CMo is an inventor of several US and International Georgetown University patents to use tyrosine kinase inhibitors (TKis) for the treatment of neurodegenerative diseases. CMo is a co-founder and shareholder and receives consulting fees from KeifeRx LLC. CMo receives consulting fees from Neumentum LLC, SUn Pharmaceuticals Research Industry, and SkyBIo. CMo received NIH NIA funding, Alzheimer's Association, and Sun Pharmaceuticals Research Industry Funding to study TKis in neurodegeneration, including LBD. KP has received consulting fees from Curasen and is funded by grants from the NIH, Michael J Fox Foundation for Parkinson's Research, LBDA, and Alzheimer's Drug Discovery Foundation, and has received funding from Sanofi US Services, Inc. to perform clinical trials. MS declares ownership interest (Stock or stock options): Brain Health Inc, NeuroTau, Optimal Cognitive Health Company, uMethod Health, Versanum, Athira, Cognoptix and consulting work for Alzheon, Biogen, Cortexyme, Roche Genentech, Stage 2 Innovations/Renew Research, Acadia, T3D, Eisai, KeifeRx. MS also declares royalties: HarperCollins, Humanix and speakers bureau: Health and Wellness Partners. LR receives grant funding from the NINDS, Michael J. Fox Foundation, Parkinson's Foundation, and National Ataxia Foundation. She has also served on advisory boards for Uniqure and other pharmaceutical companies through the Parkinson's Study Group. MJA receives research support from the NIA (R01AG068128, P30AG047266), the Florida Department of Health (Grant 20A08), and as the local PI of a Lewy Body Dementia Association Research Center of Excellence. MJA serves on the data safety monitoring boards (DSMBs) for ACTC/ATRI and ADCS. MJA receives royalties from the publication of the book Parkinson's Disease: Improving Patient Care. MJA serves on the level of evidence editorial board for Neurology and related publications (uncompensated). JGG declares grants/research—Acadia, Michael J. Fox Foundation, Parkinson's Foundation, Consultant—Worldwide Med, Honoraria—American Academy of Neurology, Davis Phinney Foundation, International Parkinson and Movement Disorders Society, Medscape, Parkinson's Foundation, Other: Lewy Body Dementia Association Research Center of Excellence. ZM received institutional grant support from NIH, MJFF, LBDA, Parkinson's Foundation, Eli Lilly, NeuroDerm, Cerevel Therapeutics and personal consulting honoraria from Global Kinetics Corporation, GB Sciences, ACADIA, PSG, Elsevier, Kyowa Kirin, AbbVie, and Supernus. IL's research is supported by the National Institutes of Health Grants: 2R01AG038791-06A, U01NS100610, U01NS80818, R25NS098999; U19 AG063911-1 and 1R21NS114764-01A1; the Michael J Fox Foundation, Parkinson Foundation, Lewy Body Association, CurePSP, Roche, Abbvie, Biogen, Centogene. EIP-Pharma, Biohaven Pharmaceuticals, Novartis, Brain Neurotherapy Bio, and United Biopharma SRL—UCB. IL was a member of the Scientific Advisory Board of Lundbeck and is a Scientific Advisor for Amydis and Rossy Center for the Progressive Supranuclear Palsy University of Toronto. IL receives her salary from the University of California San Diego and as Chief Editor of Frontiers in Neurology. JL receives grant funding from the NIH/NIA/NINDS (P30AG072959/P30AG062428/U01NS100610), LBDA, GE Healthcare and serves as a consultant for Eisai Pharmaceuticals. RW serves on the data safety monitoring boards for Alexion, Bukwang, and Sarepta Pharmaceuticals and the Scientific Platform Steering Committee for Adams Pharmaceuticals. RW serves as a consultant for Lundbeck, Acadia, Teva, Abbvie, Alexion, Adamas, Prime, Bukwang, Sarepta, Syneos, Techspert, Guidepoint and also for R01R01NS117547 with Principal Investigator, Virendra Mishra. AL has received research support from the Dutch Research Council (ZonMW), Alzheimer Netherlands, Dioraphte Foundation, AL has given lectures in symposia sponsored by GE. CG is a scientific consultant and has stock in CND Life Sciences. SG has served on Advisory Boards of Jannsen, Acadia, and Sanofi, has received consulting fees from EIP Pharma, and has received funding from the NIH, the DOD CDMRP, the Michael J. Fox Foundation, the FFFPRI, and the Lewy Body Dementia Association. BB has served as an investigator for clinical trials sponsored by Alector, EIP Pharma, and Biogen. He serves on the Scientific Advisory Board of the Tau Consortium. He receives institutional research support from the NIH, the Lewy Body Dementia Association Research Centers of Excellence Program, the Mayo Clinic Dorothy and Harry T. Mangurian Jr. Lewy Body Dementia Program, the Little Family Foundation, and the Ted Turner and Family Foundation. AP serves on the Scientific Advisory Board of MedRhythms, Inc. and receives research support from the Lewy Body Dementia Association (as Co-Director of the Johns Hopkins LBDA Research Center of Excellence) and NIH/NINDS/NIA (U01NS102035; K23AG059891). DG receives research support from NIA (AG062429), the State of California, and the Michael J. Fox Foundation, which is a paid consultant for Biogen, Roche, Esai, Cognition Therapeutics, Fujirebio, Amprion, Generian, and Editor of Alzheimer's Research & Therapy. DH is supported by The Michael J. Fox Foundation (MJFF-010556), NIH-NINDS 1K23NS105944-01A1, the American Parkinson's Disease Association Center for Advanced Research (Emory University), and the Lewy Body Dementia Association Research Center of Excellence (Emory University). JF is on the editorial board of the American Academy of Neurology's Brain and Life magazine (uncompensated), Lewy Body Dementia Association Scientific Affairs Committee (uncompensated), and has received honoraria from Parkinson's Foundation. JF receives grant funding from the NIH/NIA/NINDS (K23NS097615, 5P30AG064200-02), CurePSP, and Parkinson's Foundation. KD-R receives research funding from the NIH (P30 AG066509) and LBDA Research Center of Excellence; has served on a Biogen advisory board; receives speakers honoraria from MedBridge. LS receives research support from NIH/NIA U19 AG024904, ADNI3 grant; NIH/NIA P30 AG010124, UPENN ADCC grant; and the Michael J. Fox Foundation for Parkinson's Research. He is a consultant for Biogen and Roche Diagnostics and is on the speaker's bureaus for Biogen and Fujirebio. DI receives research funding from NIH (R01-NS109260, P01-AG066597, U19-AG062418, U01-NS100610), Penn Institute on Aging and is the co-PI of the Penn LBDA Research Centers of Excellence. He is a member of the scientific advisory board of Denali Therapeutics. LH is a paid consultant for Biogen, Cortexyme, Eisai, Medscape, and Prevail. LH receives grant support from NIA, NINDS, LBDA, Acumen, Alector, Avanir, Eisai, Genentech/Roche, Janssen/Johnson & Johnson, NovoNordisk, Transposon, UCB, and Vaccinex. JD receives research funding from NIH, the Department of Veterans Affairs, the Michael J. Fox Foundation and Innervace, Inc. He is also the co-PI of the Penn LBDA Research Center of Excellence. IL is the Editor in Chief of the journal but she was not involved in the process of referee selection, peer review or the acceptance decision. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.