Effect of Genetic Variants of Gonadotropins and Their Receptors on Ovarian Stimulation Outcomes: A Delphi Consensus.

Background

A Delphi consensus was conducted to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding gonadotropin and gonadotropin receptors on clinical ovarian stimulation outcomes following assisted reproductive technology (ART) treatment.

Methods

Nine experts plus two Scientific Coordinators discussed and amended statements plus supporting references proposed by the Scientific Coordinators. The statements were distributed

Results

Eleven statements were developed, of which two statements were merged. Overall, eight statements achieved consensus and two statements did not achieve consensus. The statements reaching consensus are summarized here. (1) SNP in the follicle stimulating hormone receptor (

Conclusions

This Delphi consensus provides clinical perspectives from a diverse international group of experts. The consensus supports a link between some variants in gonadotropin/gonadotropin receptor genes and ovarian stimulation outcomes; however, further research is needed to clarify these findings.

Informations de copyright

Copyright © 2022 Conforti, Tüttelmann, Alviggi, Behre, Fischer, Hu, Polyzos, Chuderland, Rama Raju, D’Hooghe, Simoni, Sunkara and Longobardi.

Déclaration de conflit d'intérêts

The Delphi consensus was coordinated by a healthcare consulting and training company (Sanitanova Srl, Milan, Italy). The consensus concept was initiated and funded by Merck KGaA, Darmstadt, Germany. The sponsor was involved early in the process, defining the overarching topic to be discussed, but did not participate in the development of the statements or in any of the meetings or discussions involved in developing the Delphi consensus. The statements were, therefore, developed independently of the industry sponsor. The authors from Merck KGaA, Darmstadt, Germany, were only involved in the development of the manuscript, critically revising it for important intellectual content, especially in the Introduction, Results and Discussion sections, but could not alter the consensus statements in any way. DC, TD’H, and SL are employees of Merck KGaA, Darmstadt, Germany. AC has received of honoraria and consultation from Merck KGaA, Darmstadt, Germany and Event Planet SpA. CA has received of honoraria for lectures from Merck KGaA, Darmstadt, Germany and Event Planet SpA. HB has been scientific advisor for Merck KGaA, Darmstadt, Germany and MSD. RF has received honoraria from Merck KGaA, Darmstadt, Germany and affiliates for lectures. NP received research grants or honoraria for lectures from: Merck KGaA, Darmstadt, Germany, MSD, Ferring Pharmaceuticals, Besins International, Roche Diagnostics, IBSA, Theramex, Gedeon Richter. MS received honoraria and research grants from Merck KGaA, Darmstadt, Germany, Ferring and IBSA. SS was a speaker at non-promotional educational symposia by Merck KGaA, Darmstadt, Germany and Ferring, and received independent research grants from Merck KGaA, Darmstadt, Germany and Ferring. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.