Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy

Animals Apoptosis Cannabidiol / metabolism Cell Survival Mice Naltrexone / pharmacology
cannabidiol chemotherapy combination therapy drug‑sequence low‑dose naltrexone

Journal

Oncology reports
ISSN: 1791-2431
Titre abrégé: Oncol Rep
Pays: Greece
ID NLM: 9422756

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 25 10 2021
accepted: 24 01 2022
entrez: 18 2 2022
pubmed: 19 2 2022
medline: 22 2 2022
Statut: ppublish

Résumé

We previously reported that both cannabidiol (CBD) and low‑dose naltrexone (LDN) exhibit complex effects on G‑protein coupled receptors, which can impact the expression and function of other members of this superfamily. These receptors feed into and interact with central signalling cascades that determine the ease by which cells engage in apoptosis, and can be used as a way to prime cancer cells to other treatments. The present study was designed to investigate the effect of combining these two agents on cancer cell lines

Identifiants

DOI: 10.3892/or.2022.8287 PMID: 35179218
pubmed: 35179218
doi: 10.3892/or.2022.8287
pii: 76
doi:
pii:

Substances chimiques

Cannabidiol 19GBJ60SN5
Naltrexone 5S6W795CQM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Wai M Liu (WM)

Institute for Infection and Immunity, St George's University of London, London SW17 0RE, UK.

Nadine K Hall (NK)

Institute for Infection and Immunity, St George's University of London, London SW17 0RE, UK.

Harry S Y Liu (HSY)

Institute for Infection and Immunity, St George's University of London, London SW17 0RE, UK.

Francis L Hood (FL)

LDN Pharma Ltd., London EC2R 6AY, UK.

Angus G Dalgleish (AG)

Institute for Infection and Immunity, St George's University of London, London SW17 0RE, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Combination of cannabidiol with low‑dose...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Combination of cannabidiol with low‑dose...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Cannabidiol › Combination of cannabidiol with low‑dose...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Combination of cannabidiol with low‑dose...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Combination of cannabidiol with low‑dose...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Naloxone › Naltrexone › Combination of cannabidiol with low‑dose...