Creation and maintenance of neo-vagina with the use of vaginal dilators as first line treatment: Results from a quaternary paediatric and adolescent gynaecology service in Australia.


Journal

The Australian & New Zealand journal of obstetrics & gynaecology
ISSN: 1479-828X
Titre abrégé: Aust N Z J Obstet Gynaecol
Pays: Australia
ID NLM: 0001027

Informations de publication

Date de publication:
06 2022
Historique:
pubmed: 19 2 2022
medline: 23 6 2022
entrez: 18 2 2022
Statut: ppublish

Résumé

Vaginal agenesis is an uncommon condition with an estimated incidence of 1/5000 live female births. There are surgical and non-surgical treatment options for neo-vagina creation. Vaginal dilatation has been used to treat vaginal agenesis for over 80 years, but outcome data to date have had poor definitions for 'success'. The optimal method for neo-vagina creation varies with vaginal dilator therapy being the most successful first line therapy in women with Mayer-Rokistansky-Kuster-Hauser syndrome, with little literature to guide best practice in women with more complex congenital conditions. There is a paucity of data from Australian and New Zealand paediatric and adolescent gynaecology services on management of women requiring a functional vagina, for any underlying aetiology. To determine if creation and maintenance of a functional neo-vagina for vaginal agenesis with non-surgical management (via vaginal dilators) should be the first line treatment. Retrospective observational study between January 2005 and June 2015. Of the 23 women, 21 (91.3%) achieved a successful vaginal length defined as achieving vaginal length >6 cm and maximum width using the largest dilator if not sexually active, or ability to have sexual intercourse without discomfort. Vaginal dilator therapy remains an effective first line treatment for neo-vagina creation and maintenance and can be achieved in an outpatient setting with appropriate support.

Sections du résumé

BACKGROUND
Vaginal agenesis is an uncommon condition with an estimated incidence of 1/5000 live female births. There are surgical and non-surgical treatment options for neo-vagina creation. Vaginal dilatation has been used to treat vaginal agenesis for over 80 years, but outcome data to date have had poor definitions for 'success'. The optimal method for neo-vagina creation varies with vaginal dilator therapy being the most successful first line therapy in women with Mayer-Rokistansky-Kuster-Hauser syndrome, with little literature to guide best practice in women with more complex congenital conditions. There is a paucity of data from Australian and New Zealand paediatric and adolescent gynaecology services on management of women requiring a functional vagina, for any underlying aetiology.
AIMS
To determine if creation and maintenance of a functional neo-vagina for vaginal agenesis with non-surgical management (via vaginal dilators) should be the first line treatment.
MATERIALS AND METHODS
Retrospective observational study between January 2005 and June 2015.
RESULTS
Of the 23 women, 21 (91.3%) achieved a successful vaginal length defined as achieving vaginal length >6 cm and maximum width using the largest dilator if not sexually active, or ability to have sexual intercourse without discomfort.
CONCLUSION
Vaginal dilator therapy remains an effective first line treatment for neo-vagina creation and maintenance and can be achieved in an outpatient setting with appropriate support.

Identifiants

pubmed: 35179224
doi: 10.1111/ajo.13487
doi:

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

439-444

Informations de copyright

© 2022 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

Références

Laufer MR. Congenital anomalies of the hymen and vagina. UpToDate. Retrieved Aug 1 2021.
ACOG Committee on Adolescent Health Care. Vaginal agenesis: diagnosis, management and routine care. Obstet Gynecol 2006; 108: 1605.
Edmonds DK. Congenital malformations of the genital tract and their management. Best Pract Res Clin Obstet Gynecol 2003; 17: 19.
Roberts CP, Haber MJ, Rock JA. Vaginal creation for mullerian agenesis. Am J Obstet Gynecol 2001; 185: 1349-1352.
Frank RT. The formation of artificial vagina without operation. Am J Obstet Gynecol 1938; 35: 1035-1055.
Edmonds DK, Rose GL, Lipton MG, Quek J. Mayer-Rokitansky-Küster-Hauser syndrome: a review of 245 consecutive cases managed by a multidisciplinary approach with vaginal dilators. Fertil Steril 2012; 97: 686-690.
Ketheeswaran A, Morrisey J, Abbott J, et al. Intensive vaginal dilation using adjuvant treatments in women with Mayer-Rokitansky-Kuster-Hauser syndrome: retrospective cohort study. Aust N Z J Obstet Gynaecol 2018; 58(1): 108-113.
Davies MC, Creighton SM, Woodhouse CR. The pitfalls of vaginal construction. BJU Int 2005; 95: 1293-1298.
Routh JC, Laufer MR, Cannon GM Jr, et al. Management strategies for Mayer-Rokitansky-Kuster-Hauser related vaginal agenesis: A cost-effectiveness analysis. J Urol 2010; 184: 2116-2122.
Bean EJ, Mazur T, Robinson AD. Mayer-Rokitansky-Kuster-Hauser Syndrome: Sexuality, psychological effects and quality of life. J Pediatr Adolesc Gynecol 2009; 22: 339-346.
Ingram JM. The bicycle seat stool in the treatment of vaginal agenesis and stenosis: a preliminary report. Am J Obstet Gynecol 1981; 140: 867-873.
Rock JA, Reeves LA, Retto H, et al. Success following vaginal creation for millerian agenesis. Fertil Steril 1983; 39: 809-813.
Broadbent TR, Woolf RM, Hebertson R. Nonoperative construction of the vagina: two unusual cases. Plast Reconstr Surg 1984; 73: 117-123.

Auteurs

Amanda Wee (A)

Royal Brisbane and Women's Hospital, Women's and Newborns Services, Brisbane, Queensland, Australia.

Tapasi Bagchi (T)

Royal Brisbane and Women's Hospital, Women's and Newborns Services, Brisbane, Queensland, Australia.

Rebecca Kimble (R)

Royal Brisbane and Women's Hospital, Women's and Newborns Services, Brisbane, Queensland, Australia.

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