Mortality prediction of septic patients by blood caspase-8 levels.
Apoptosis
Caspase-8
Mortality
Outcome
Sepsis
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
02
11
2021
revised:
07
01
2022
accepted:
16
01
2022
pubmed:
19
2
2022
medline:
23
3
2022
entrez:
18
2
2022
Statut:
ppublish
Résumé
We have not found data about blood caspase-8 concentrations (initiator caspase in the extrinsic pathway of apoptosis) during follow-up of sepsis and this was the objective of our study. We included septic patients. Serum caspase-8 concentrations were determined at days 1, 4, and 8 of sepsis diagnosis. We registered mortality at 30 days. Nonsurviving patients (n = 89) in respect to surviving patients (n = 160) showed higher serum caspase-8 levels at days 1 (P < 0.001), 4 (P <0.001), and 8 (P <0.001) of sepsis diagnosis. Serum caspase-8 levels on day 1, day 4, and day 8 had an area under curve for the prediction of 30-day mortality of 68% (60%-75%, P<0.001), 72% (62%-82%, P<0.001), and 81% (73%-90%, P<0.001). Thus, that blood caspase-8 concentrations at any time during the first week of sepsis were higher in non-survivor than in survivor patients and that were able to predict mortality were new findings in our study.
Identifiants
pubmed: 35180643
pii: S0732-8893(22)00007-4
doi: 10.1016/j.diagmicrobio.2022.115639
pii:
doi:
Substances chimiques
CASP8 protein, human
EC 3.4.22.-
Caspase 8
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115639Informations de copyright
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