Time Course of Activity-Dependent Changes in Auditory Nerve Synapses Reveals Multiple Underlying Cellular Mechanisms.
activity-dependent changes
auditory nerve
cochlear nucleus
endbulb of Held
synaptic plasticity
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
23 03 2022
23 03 2022
Historique:
received:
03
08
2021
revised:
10
01
2022
accepted:
28
01
2022
pubmed:
20
2
2022
medline:
23
4
2022
entrez:
19
2
2022
Statut:
ppublish
Résumé
Abnormal levels of acoustic activity can result in hearing problems such as tinnitus and language processing disorders, but the underlying cellular and synaptic changes triggered by abnormal activity are not well understood. To address this issue, we studied the time course of activity-dependent changes that occur at auditory nerve synapses in mice of both sexes after noise exposure and conductive hearing loss. We found that EPSC amplitude and synaptic depression decreased within 2 d of noise exposure through a decrease in the probability of vesicle release (
Identifiants
pubmed: 35181597
pii: JNEUROSCI.1583-21.2022
doi: 10.1523/JNEUROSCI.1583-21.2022
pmc: PMC8944231
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2492-2502Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC015508
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
Références
J Neurosci. 2020 Sep 2;40(36):6896-6909
pubmed: 32747441
J Microsc. 2005 Apr;218(Pt 1):52-61
pubmed: 15817063
Neuron. 2013 Oct 16;80(2):327-34
pubmed: 24139037
J Physiol. 2006 Apr 15;572(Pt 2):313-21
pubmed: 16469782
Nature. 2011 Jun 26;475(7357):501-5
pubmed: 21706031
Proc Natl Acad Sci U S A. 2015 May 19;112(20):6479-84
pubmed: 25944933
Nat Neurosci. 2000 Jun;3(6):545-50
pubmed: 10816309
J Neurophysiol. 2006 Oct;96(4):2127-33
pubmed: 16760351
J Neurophysiol. 2010 Apr;103(4):1915-26
pubmed: 20107122
Neuron. 2004 Sep 30;44(1):5-21
pubmed: 15450156
Neuron. 2008 Mar 13;57(5):705-18
pubmed: 18341991
J Physiol. 2002 Mar 15;539(Pt 3):713-23
pubmed: 11897843
Neuron. 1998 Dec;21(6):1235-8
pubmed: 9883717
Cold Spring Harb Perspect Biol. 2012 Jan 01;4(1):a005736
pubmed: 22086977
J Physiol. 2014 Apr 1;592(7):1581-600
pubmed: 24469075
Neuron. 2004 Jul 8;43(1):119-31
pubmed: 15233922
Nat Neurosci. 2006 Sep;9(9):1117-24
pubmed: 16892056
Pediatrics. 1969 May;43(5):833-9
pubmed: 5769509
Neuron. 2016 Jan 20;89(2):337-50
pubmed: 26774161
J Neurosci. 2007 Dec 26;27(52):14404-14
pubmed: 18160648
J Neurosci. 2017 Jan 11;37(2):323-332
pubmed: 28077712
Nat Commun. 2019 Feb 18;10(1):826
pubmed: 30778063
Neuroscience. 2005;136(3):843-63
pubmed: 16344156
J Neurophysiol. 2009 Sep;102(3):1699-710
pubmed: 19587324
J Neurophysiol. 2010 Nov;104(5):2308-20
pubmed: 20739600
Nature. 1998 Feb 26;391(6670):892-6
pubmed: 9495341
J Comp Neurol. 1982 Sep 20;210(3):239-57
pubmed: 7142440
J Neurosci. 2019 Oct 16;39(42):8347-8361
pubmed: 31451577
J Neurosci. 2016 Sep 28;36(39):10214-27
pubmed: 27683915
Neuron. 2019 Jul 3;103(1):8-20
pubmed: 31271756
Curr Biol. 2021 Jun 7;31(11):2274-2285.e5
pubmed: 33798429
Physiol Rev. 2010 Jul;90(3):983-1012
pubmed: 20664077
Neuron. 2013 Oct 16;80(2):335-42
pubmed: 24139038
J Neurosci. 2001 Oct 15;21(20):7889-900
pubmed: 11588162
Physiol Rev. 2004 Jan;84(1):69-85
pubmed: 14715911
J Neurophysiol. 2009 Nov;102(5):2627-37
pubmed: 19726731
J Comp Neurol. 1991 Mar 1;305(1):35-48
pubmed: 2033123
J Neurophysiol. 2010 Oct;104(4):2063-74
pubmed: 20702743
J Physiol. 2004 Nov 1;560(Pt 3):709-19
pubmed: 15331689
Annu Rev Physiol. 1999;61:497-519
pubmed: 10099699
J Neurophysiol. 2008 Sep;100(3):1255-64
pubmed: 18632895
EMBO J. 2014 Mar 3;33(5):512-27
pubmed: 24442636
Nature. 2002 Nov 28;420(6914):414-8
pubmed: 12459783
Curr Opin Neurobiol. 2009 Apr;19(2):188-99
pubmed: 19535241
Curr Opin Physiol. 2020 Dec;18:7-10
pubmed: 33103017
Neuron. 2021 Feb 3;109(3):530-544.e6
pubmed: 33232655
J Neurosci Methods. 2003 Dec 15;130(2):127-41
pubmed: 14667542
Cold Spring Harb Perspect Biol. 2012 Feb 01;4(2):
pubmed: 22147943
J Assoc Res Otolaryngol. 2011 Oct;12(5):535-47
pubmed: 21607783
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9
pubmed: 20439739
Annu Rev Neurosci. 2006;29:307-23
pubmed: 16776588
J Neurosci. 1999 Aug 1;19(15):6427-38
pubmed: 10414971
PLoS One. 2013 Aug 26;8(8):e73308
pubmed: 23991186
Neuron. 2008 Sep 25;59(6):882-901
pubmed: 18817729