E-Protein Inhibition in ILC2 Development Shapes the Function of Mature ILC2s during Allergic Airway Inflammation.
Adaptor Proteins, Signal Transducing
/ genetics
Allergens
/ immunology
Animals
Antigens, Dermatophagoides
/ immunology
Asthma
/ immunology
Cell Differentiation
/ immunology
Chromatin
/ metabolism
Cytokines
/ immunology
DNA-Binding Proteins
/ antagonists & inhibitors
Female
Inhibitor of Differentiation Protein 1
/ metabolism
Lectins, C-Type
/ genetics
Lung
/ immunology
Male
Mice
Mice, Inbred C57BL
Pyroglyphidae
/ immunology
Receptors, Immunologic
/ genetics
Stem Cells
/ cytology
T-Lymphocytes
/ cytology
Transcription Factor AP-1
/ metabolism
Transcription Factors
/ metabolism
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
03
05
2021
accepted:
09
12
2021
pubmed:
20
2
2022
medline:
8
3
2022
entrez:
19
2
2022
Statut:
ppublish
Résumé
E-protein transcription factors limit group 2 innate lymphoid cell (ILC2) development while promoting T cell differentiation from common lymphoid progenitors. Inhibitors of DNA binding (ID) proteins block E-protein DNA binding in common lymphoid progenitors to allow ILC2 development. However, whether E-proteins influence ILC2 function upon maturity and activation remains unclear. Mice that overexpress ID1 under control of the thymus-restricted proximal
Identifiants
pubmed: 35181641
pii: jimmunol.2100414
doi: 10.4049/jimmunol.2100414
pmc: PMC8881320
mid: NIHMS1764286
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Allergens
0
Antigens, Dermatophagoides
0
Chromatin
0
Cytokines
0
DNA-Binding Proteins
0
Idb1 protein, mouse
0
Inhibitor of Differentiation Protein 1
0
Klrg1 protein, mouse
0
Lectins, C-Type
0
Receptors, Immunologic
0
Sh2d2a protein, mouse
0
Transcription Factor AP-1
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1007-1020Subventions
Organisme : NIAID NIH HHS
ID : DP2 AI136596
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010346
Pays : United States
Organisme : NIH HHS
ID : S10 OD024979
Pays : United States
Organisme : NIAID NIH HHS
ID : K22 AI116729
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132708
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130379
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI126851
Pays : United States
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.
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