Chest X-rays are less sensitive than multiple breath washout examinations when it comes to detecting early cystic fibrosis lung disease.
chest X-rays
chest computed tomography
cystic fibrosis lung disease
lung clearance index
multiple breath washout
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
15
02
2022
received:
16
11
2021
accepted:
16
02
2022
pubmed:
20
2
2022
medline:
14
5
2022
entrez:
19
2
2022
Statut:
ppublish
Résumé
Annual chest X-ray is recommended as routine surveillance to track cystic fibrosis (CF) lung disease. The aim of this study was to investigate the clinical utility of chest X-rays to track CF lung disease. Children at Gothenburg's CF centre who underwent chest X-rays, multiple breath washouts and chest computed tomography examinations between 1996 and 2016 were included in the study. Chest X-rays were interpreted with Northern Score (NS). We compared NS to lung clearance index (LCI) and structural lung damage measured by computed tomography using a logistic regression model. A total of 75 children were included over a median period of 13 years (range: 3.0-18.0 years). The proportion of children with abnormal NS was significantly lower than the proportion of abnormal LCI up to the age of 4 years (p < 0.05). A normal NS and a normal LCI at age 6 years were associated with a median (10-90th percentile) total airway disease of 1.8% (0.4-4.7%) and bronchiectasis of 0.2% (0.0-1.5%). Chest X-rays were less sensitive than multiple breath washout examinations to detect early CF lung disease. The combined results from both methods can be used as an indicator to perform chest computed tomography less frequently.
Identifiants
pubmed: 35181935
doi: 10.1111/apa.16302
pmc: PMC9306859
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1253-1260Subventions
Organisme : Queen Silvia's children hospital research foundation
Organisme : Samariten foundation for paediatric research
Organisme : The Swedish CF foundation
Organisme : Freemasons order foundation
Organisme : Erica Lederhausen foundation
Organisme : Petter Silverskiolds foundation
Informations de copyright
© 2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
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