Chronic inflammation as a potential mediator between phthalate exposure and depressive symptoms.

Aged Depression / chemically induced Dibutyl Phthalate Environmental Exposure / adverse effects Environmental Pollutants / toxicity Humans Inflammation / chemically induced Phthalic Acids / toxicity
Depressive symptoms Inflammatory factors Mediation effect PAEs The elderly

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
15 Mar 2022
Historique:
received: 09 11 2021
revised: 11 02 2022
accepted: 12 02 2022
pubmed: 20 2 2022
medline: 16 3 2022
entrez: 19 2 2022
Statut: ppublish

Résumé

A few studies have reported phthalate exposure as a risk factor for depressive symptoms, but the results have been inconsistent. Whether chronic inflammation mediates the relationship between phthalates (PAEs) and depressive symptoms remains unclear. In this study, we establish mediating models of inflammatory factors and explore the mediating role of chronic inflammation in the association between PAEs exposure and depressive symptoms. The sample included 989 participants from the Study on Health and Environment of the Elderly in Lu'an City, Anhui Province. Geriatric depression scale (GDS-30) was used to screen depressive symptoms of the elderly. The levels of seven kinds of PAEs in urine samples and four inflammatory factors in serum of the elderly were measured. To establish the mediating effect of inflammatory factors to explore the potential effect of PAEs exposure on the increased odds of depressive symptoms. Adjusted for multiple variables, the highest tertiles of Mono (2-ethylhexyl) phthalate (MEHP) (95%CI = 1.051-2.112), Mono benzyl phthalate (MBzP) (95%CI = 1.016-2.082) and Mono butyl phthalate (MBP) (95%CI = 1.102-2.262) were positively correlated with depressive symptoms. The mediating effect of IL-6 and generalized inflammation factor between MEHP exposure and depressive symptoms were 15.96% (95%CI=0.0288-0.1971) and 14.25% (95%CI = 0.0167-0.1899). High levels of MEHP, MBzP and MBP increased the odds of depressive symptoms in the elderly, and chronic inflammation had a partial mediating effect on the increased odds of depressive symptoms due to MEHP exposure.

Sections du résumé

BACKGROUND BACKGROUND
A few studies have reported phthalate exposure as a risk factor for depressive symptoms, but the results have been inconsistent. Whether chronic inflammation mediates the relationship between phthalates (PAEs) and depressive symptoms remains unclear. In this study, we establish mediating models of inflammatory factors and explore the mediating role of chronic inflammation in the association between PAEs exposure and depressive symptoms.
METHODS METHODS
The sample included 989 participants from the Study on Health and Environment of the Elderly in Lu'an City, Anhui Province. Geriatric depression scale (GDS-30) was used to screen depressive symptoms of the elderly. The levels of seven kinds of PAEs in urine samples and four inflammatory factors in serum of the elderly were measured. To establish the mediating effect of inflammatory factors to explore the potential effect of PAEs exposure on the increased odds of depressive symptoms.
RESULTS RESULTS
Adjusted for multiple variables, the highest tertiles of Mono (2-ethylhexyl) phthalate (MEHP) (95%CI = 1.051-2.112), Mono benzyl phthalate (MBzP) (95%CI = 1.016-2.082) and Mono butyl phthalate (MBP) (95%CI = 1.102-2.262) were positively correlated with depressive symptoms. The mediating effect of IL-6 and generalized inflammation factor between MEHP exposure and depressive symptoms were 15.96% (95%CI=0.0288-0.1971) and 14.25% (95%CI = 0.0167-0.1899).
CONCLUSIONS CONCLUSIONS
High levels of MEHP, MBzP and MBP increased the odds of depressive symptoms in the elderly, and chronic inflammation had a partial mediating effect on the increased odds of depressive symptoms due to MEHP exposure.

Identifiants

DOI: 10.1016/j.ecoenv.2022.113313 PMID: 35182801
pubmed: 35182801
pii: S0147-6513(22)00153-1
doi: 10.1016/j.ecoenv.2022.113313
pii:
doi:

Substances chimiques

Environmental Pollutants 0
Phthalic Acids 0
Dibutyl Phthalate 2286E5R2KE
phthalic acid 6O7F7IX66E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113313

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Chao Bao (C)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Jia Lv (J)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Jian-Rong Chen (JR)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Guo-Zhang Wei (GZ)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Nuo Liu (N)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Yi-Tao Wang (YT)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Zheng Ding (Z)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Wei-Bo Liu (WB)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China.

Xiu-de Li (XD)

Department of Toxicology, School of Public Health, Anhui Medical University, China.

Hong-Juan Cao (HJ)

Lu'an Center of Disease Control and Prevention, China.

Jie Sheng (J)

Department of Toxicology, School of Public Health, Anhui Medical University, China.

Kai-Yong Liu (KY)

Department of Toxicology, School of Public Health, Anhui Medical University, China.

Jun He (J)

San li an Street Community Health Service Center, Shushan District, China.

Fang-Biao Tao (FB)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Department of Maternal, Child and Adolescent Health Care, School of Public Health, Anhui Medical University, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, China. Electronic address: taofangbiao@126.com.

Qu-Nan Wang (QN)

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China; Department of Maternal, Child and Adolescent Health Care, School of Public Health, Anhui Medical University, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, China. Electronic address: wqn@ahmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Chronic inflammation as a potential mediator...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Chronic inflammation as a potential mediator...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acides phtaliques › Phtalate de dibutyle › Chronic inflammation as a potential mediator...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Chronic inflammation as a potential mediator...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Chronic inflammation as a potential mediator...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chronic inflammation as a potential mediator...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Chronic inflammation as a potential mediator...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acides phtaliques › Chronic inflammation as a potential mediator...