Mechanosensitive modulation of peristaltic contractions in the mouse renal pelvis.

Animals Calcitonin Gene-Related Peptide / pharmacology Capsaicin / pharmacology Kidney Pelvis / physiology Mice Muscle Contraction Myocytes, Smooth Muscle Peristalsis TRPV Cation Channels
Atypical smooth muscle cell Pyeloureteral peristalsis TRPV1 TRPV4 Typical smooth muscle cell

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
05 Apr 2022
Historique:
received: 17 06 2021
revised: 02 02 2022
accepted: 15 02 2022
pubmed: 21 2 2022
medline: 8 4 2022
entrez: 20 2 2022
Statut: ppublish

Résumé

The renal pelvis develops spontaneous phasic contractions (SPCs) that underlie pyeloureteric peristalsis. Increased urine flow into the renal pelvis mechanically stimulates the contractile machinery within the renal pelvis to facilitate the propagation of peristalsis. Here, the effects of mechanostimulation of the pelvicalyceal junction (PCJ), where SPCs originate from, on the properties of SPCs were investigated. Using the wire myograph, isometric tension changes in tubular preparations of mouse renal pelvis with calyces were circumferentially measured, while mechanostimuli were applied to the PCJ. Immunohistochemistry and intracellular Ca

Identifiants

DOI: 10.1016/j.ejphar.2022.174834 PMID: 35183536
pubmed: 35183536
pii: S0014-2999(22)00095-4
doi: 10.1016/j.ejphar.2022.174834
pii:
doi:

Substances chimiques

TRPV Cation Channels 0
Trpv4 protein, mouse 0
Calcitonin Gene-Related Peptide JHB2QIZ69Z
Capsaicin S07O44R1ZM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

174834

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Mikako Yoshikawa (M)

Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Retsu Mitsui (R)

Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Hiromichi Takano (H)

Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Hikaru Hashitani (H)

Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. Electronic address: hasitani@med.nagoya-cu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanosensitive modulation of peristaltic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide relié au gène de la calcitonine › Mechanosensitive modulation of peristaltic...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Capsaïcine › Mechanosensitive modulation of peristaltic...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Pelvis rénal › Mechanosensitive modulation of peristaltic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mechanosensitive modulation of peristaltic...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Mechanosensitive modulation of peristaltic...