Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site.

Binding Sites Calcium / metabolism Heme / metabolism Hemin / metabolism Hydrogen Sulfide / metabolism Iron / metabolism Large-Conductance Calcium-Activated Potassium Channels / metabolism

Journal

The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362

Informations de publication

Date de publication:
05 2022
Historique:
received: 03 12 2021
accepted: 10 02 2022
pubmed: 21 2 2022
medline: 21 4 2022
entrez: 20 2 2022
Statut: ppublish

Résumé

Reperfusion together with the preceding ischemic period results in serious damage to brain and heart tissues. Activation of potassium channels from the inner mitochondrial membrane leads to cytoprotection during such events. The mitochondrial large-conductance calcium-activated potassium channel (mitoBK

Identifiants

DOI: 10.1124/jpet.121.001017 PMID: 35184043
pubmed: 35184043
pii: jpet.121.001017
doi: 10.1124/jpet.121.001017
doi:

Substances chimiques

Large-Conductance Calcium-Activated Potassium Channels 0
Heme 42VZT0U6YR
Hemin 743LRP9S7N
Iron E1UOL152H7
Calcium SY7Q814VUP
Hydrogen Sulfide YY9FVM7NSN

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

137-150

Informations de copyright

Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Agnieszka Walewska (A)

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Adam Szewczyk (A)

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Milena Krajewska (M)

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Piotr Koprowski (P)

Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland p.koprowski@nencki.edu.pl.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Targeting Mitochondrial Large-Conductance...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Targeting Mitochondrial Large-Conductance...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Targeting Mitochondrial Large-Conductance...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Hémine › Targeting Mitochondrial Large-Conductance...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Targeting Mitochondrial Large-Conductance...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Targeting Mitochondrial Large-Conductance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques calcium-dépendants › Canaux potassiques calcium-dépendants de grande conductance › Targeting Mitochondrial Large-Conductance...