A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion.
Animals
Autoantibodies
/ immunology
Autoantigens
/ immunology
B-Lymphocytes
/ cytology
Brain
/ metabolism
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Female
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Sclerosis
/ immunology
Myelin-Oligodendrocyte Glycoprotein
/ genetics
Receptors, Antigen, T-Cell
/ immunology
B cell
TCR1640 transgene mouse model
autoimmunity
demyelinating antibodies
experimental autoimmune encephalomyelitis (EAE)
multiple sclerosis
myelin oligodendrocyte glycoprotein (MOG)
repertoire
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
08
2021
accepted:
11
01
2022
entrez:
21
2
2022
pubmed:
22
2
2022
medline:
31
3
2022
Statut:
epublish
Résumé
The key role of B cells in the pathophysiology of multiple sclerosis (MS) is supported by the presence of oligoclonal bands in the cerebrospinal fluid, by the association of meningeal ectopic B cell follicles with demyelination, axonal loss and reduction of astrocytes, as well as by the high efficacy of B lymphocyte depletion in controlling inflammatory parameters of MS. Here, we use a spontaneous model of experimental autoimmune encephalomyelitis (EAE) to study the clonality of the B cell response targeting myelin oligodendrocyte glycoprotein (MOG). In particular, 94% of SJL/j mice expressing an I-A
Identifiants
pubmed: 35185870
doi: 10.3389/fimmu.2022.755900
pmc: PMC8850296
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
Mog protein, mouse
0
Myelin-Oligodendrocyte Glycoprotein
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
755900Informations de copyright
Copyright © 2022 Salvador, Deramoudt, Leprêtre, Figeac, Guerrier, Boucher, Bas, Journiac, Peters, Mars and Zéphir.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Brain. 2018 Jul 1;141(7):2066-2082
pubmed: 29873694
Methods Mol Biol. 2017;1623:125-133
pubmed: 28589353
Brain. 2000 Mar;123 Pt 3:508-18
pubmed: 10686174
Brain. 2007 Apr;130(Pt 4):1089-104
pubmed: 17438020
J Immunol. 2013 Sep 1;191(5):2700-7
pubmed: 23904161
Immunity. 2014 Dec 18;41(6):1040-51
pubmed: 25484301
J Exp Med. 2013 Dec 16;210(13):2921-37
pubmed: 24323356
Cell. 2018 Sep 20;175(1):85-100.e23
pubmed: 30173916
Ann Neurol. 2000 Jun;47(6):707-17
pubmed: 10852536
Nat Immunol. 2017 May;18(5):552-562
pubmed: 28346408
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3323-8
pubmed: 26957602
Sci Transl Med. 2014 Aug 6;6(248):248ra107
pubmed: 25100741
Immunity. 2016 Mar 15;44(3):542-552
pubmed: 26948373
N Engl J Med. 2017 Jan 19;376(3):221-234
pubmed: 28002679
Nature. 1985 Apr 11-17;314(6011):537-9
pubmed: 3157869
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7864-9
pubmed: 27325759
Immunity. 2012 Nov 16;37(5):893-904
pubmed: 23142780
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10719-10724
pubmed: 28893994
Neurol Neuroimmunol Neuroinflamm. 2017 Dec 22;5(2):e431
pubmed: 29296635
J Clin Invest. 1998 Sep 1;102(5):1045-50
pubmed: 9727074
JCI Insight. 2016 Dec 8;1(20):e87234
pubmed: 27942581
Annu Rev Immunol. 2012;30:221-41
pubmed: 22224776
Ann Neurol. 2010 Apr;67(4):452-61
pubmed: 20437580
Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22932-22943
pubmed: 32859762
Nat Rev Immunol. 2013 Jun;13(6):412-26
pubmed: 23681096
Nat Med. 2008 Jun;14(6):688-93
pubmed: 18488038
Brain Pathol. 2004 Apr;14(2):164-74
pubmed: 15193029
PLoS One. 2020 Feb 21;15(2):e0228883
pubmed: 32084151
Ann Neurol. 2014 Feb;75(2):266-76
pubmed: 24375699
N Engl J Med. 2008 Feb 14;358(7):676-88
pubmed: 18272891
J Exp Med. 2009 Jun 8;206(6):1303-16
pubmed: 19487416
J Immunol. 2014 Feb 1;192(3):929-39
pubmed: 24367024
Brain. 1999 Nov;122 ( Pt 11):2047-56
pubmed: 10545390
J Immunol. 2000 Nov 1;165(9):5360-6
pubmed: 11046072
Sci Transl Med. 2015 Oct 21;7(310):310ra166
pubmed: 26491076
Brain. 2009 May;132(Pt 5):1175-89
pubmed: 19339255
J Clin Invest. 1997 Jun 1;99(11):2664-71
pubmed: 9169496
J Clin Invest. 2006 Sep;116(9):2393-402
pubmed: 16955141
Nat Commun. 2011 Sep 06;2:465
pubmed: 21897376
Brain. 2014 Oct;137(Pt 10):2703-14
pubmed: 25060097
Nature. 2011 Oct 26;479(7374):538-41
pubmed: 22031325
Nature. 2014 Mar 20;507(7492):366-370
pubmed: 24572363
N Engl J Med. 2002 Sep 19;347(12):911-20
pubmed: 12239261
J Exp Med. 2003 May 5;197(9):1073-81
pubmed: 12732654
Mult Scler. 2015 Aug;21(9):1131-8
pubmed: 25480859
Sci Transl Med. 2013 Feb 20;5(173):173ra23
pubmed: 23427243
Nat Med. 2009 Jun;15(6):626-32
pubmed: 19483694
Nat Immunol. 2002 Oct;3(10):944-50
pubmed: 12244307
N Engl J Med. 2017 Jan 19;376(3):209-220
pubmed: 28002688
J Exp Med. 2012 May 7;209(5):1001-10
pubmed: 22547654