Egg-Phosphatidylcholine Attenuates T-Cell Dysfunction in High-Fat Diet Fed Male Wistar Rats.
egg
high-fat diet
immunology
obesity
phosphatidylcholine
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2021
accepted:
10
01
2022
entrez:
21
2
2022
pubmed:
22
2
2022
medline:
22
2
2022
Statut:
epublish
Résumé
Obesity is associated with immune dysfunction including an impaired T-cell function characterized by a lower IL-2 (proliferation marker) production after stimulation. Phosphatidylcholine (PC), a form of choline mostly found in eggs, has been shown to beneficially modulate T-cell responses during the lactation period by increasing the production of IL-2. To determine the impact of egg-PC as part of a high-fat diet on immune function we randomly fed male Wistar rats one of three diets containing the same amount of total choline but differing in the form of choline: 1-Control low fat [CLF, 10% wt/wt fat, 100% free choline (FC)]; 2- Control high-fat (CHF, 25% wt/wt fat, 100% FC); 3- PC high-fat (PCHF, 25% wt/wt, 100% PC). After 9 weeks of feeding, rats were euthanized. Cell phenotypes and
Identifiants
pubmed: 35187037
doi: 10.3389/fnut.2022.811469
pmc: PMC8847771
doi:
Types de publication
Journal Article
Langues
eng
Pagination
811469Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2022 Azarcoya-Barrera, Wollin, Veida-Silva, Makarowski, Goruk, Field, Jacobs and Richard.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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