Arsenic concentration in topsoil of central Chile is associated with aberrant methylation of P53 gene in human blood cells: a cross-sectional study.
DNA methylation
Epigenetics
Heavy metal
Soil pollution
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
06
09
2021
accepted:
02
02
2022
pubmed:
22
2
2022
medline:
9
7
2022
entrez:
21
2
2022
Statut:
ppublish
Résumé
Gene expression can be modified in people who are chronically exposed to high concentrations of heavy metals. The soil surrounding the Ventanas Industrial Complex, located on the coastal zone of Puchuncaví and Quintero townships (Chile), contain heavy metal concentrations (As, Cu, Pb, Zn, among others) that far exceed international standards. The aim of this study was to determine the potential association of the heavy metals in soils, especially arsenic, with the status of methylation of four tumor suppressor genes in permanent residents in those townships. To study the methylation status in genes p53, p16, APC, and RASSF1A, we took blood samples from adults living in areas near the industrial complex for at least 5 years and compared it to blood samples from adults living in areas with normal heavy metal concentrations of soils. Results indicated that inhabitants of an area with high levels of heavy metals in soil have a significantly higher proportion of methylation in the promoter region of the p53 tumor suppressor gene compared with control areas (p-value: 0.0035). This is the first study to consider associations between heavy metal exposure in humans and aberrant DNA methylation in Chile. Our results suggest more research to support consistent decision-making on processes of environmental remediation or prevention of exposure.
Identifiants
pubmed: 35188613
doi: 10.1007/s11356-022-19085-2
pii: 10.1007/s11356-022-19085-2
doi:
Substances chimiques
Metals, Heavy
0
Soil
0
Soil Pollutants
0
Tumor Suppressor Protein p53
0
Arsenic
N712M78A8G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
48250-48259Subventions
Organisme : ANID
ID : Grant 1212037
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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