Quantitative analysis of dose-averaged linear energy transfer (LET
RBE-weighted dose
dose-averaged linear energy transfer
lung cancer
pencil beam scanning
proton therapy
robustness
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
14
02
2022
received:
04
10
2021
accepted:
14
02
2022
pubmed:
24
2
2022
medline:
12
5
2022
entrez:
23
2
2022
Statut:
ppublish
Résumé
The primary objective of our study was to perform a quantitative robustness analysis of the dose-averaged linear energy transfer (LET In this study, we utilized the 4DCT dataset of six anonymized lung patients. PBS lung plans were generated using a robust optimization technique (range uncertainty: ±3.5% and setup errors: ±5 mm) on the CTV for a total dose of 5000 cGy (RBE) in five fractions using the RBE of 1.1. For each patient, the LET The mean LET The addition of setup errors to the range uncertainties resulted in slightly less homogeneous LET
Substances chimiques
Protons
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3444-3456Informations de copyright
© 2022 American Association of Physicists in Medicine.
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