Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.

Acetylcholinesterase / metabolism Caco-2 Cells Cholinesterase Inhibitors / pharmacology Dopamine Agents / pharmacology Drug Design Humans Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
10 03 2022
Historique:
pubmed: 24 2 2022
medline: 7 5 2022
entrez: 23 2 2022
Statut: ppublish

Résumé

Bioisosteric H/F or CH

Identifiants

DOI: 10.1021/acs.jmedchem.1c01784 PMID: 35195417
pubmed: 35195417
doi: 10.1021/acs.jmedchem.1c01784
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Dopamine Agents 0
Monoamine Oxidase Inhibitors 0
Monoamine Oxidase EC 1.4.3.4
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3962-3977

Auteurs

Mariagrazia Rullo (M)

Department of Pharmacy─Pharmaceutical Sciences, University of Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0001-5304-6764

Marco Cipolloni (M)

TES Pharma s.r.l., Corso Vannucci 47, 06121 Perugia, Italy.

Marco Catto (M)

Department of Pharmacy─Pharmaceutical Sciences, University of Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0002-8411-304X

Carolina Colliva (C)

TES Pharma s.r.l., Corso Vannucci 47, 06121 Perugia, Italy.
ORCID: 0000-0002-1675-3141

Daniela Valeria Miniero (DV)

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", via Orabona, 4, 70125 Bari, Italy.
ORCID: 0000-0002-3324-9692

Tiziana Latronico (T)

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", via Orabona, 4, 70125 Bari, Italy.
ORCID: 0000-0001-6971-5416

Modesto de Candia (M)

Department of Pharmacy─Pharmaceutical Sciences, University of Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.

Tiziana Benicchi (T)

TES Pharma s.r.l., Corso Vannucci 47, 06121 Perugia, Italy.

Anna Linusson (A)

Department of Chemistry, Umeå University, 90187 Umeå, Sweden.
ORCID: 0000-0003-0063-8912

Nicola Giacchè (N)

TES Pharma s.r.l., Corso Vannucci 47, 06121 Perugia, Italy.
ORCID: 0000-0002-4810-3960

Cosimo Damiano Altomare (CD)

Department of Pharmacy─Pharmaceutical Sciences, University of Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.

Leonardo Pisani (L)

Department of Pharmacy─Pharmaceutical Sciences, University of Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.
ORCID: 0000-0002-4198-3897

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents dopaminergiques › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Probing Fluorinated Motifs onto Dual AChE-MAO...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Probing Fluorinated Motifs onto Dual AChE-MAO...