Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan.
Adolescent
Adult
Age Factors
Aged
Female
Humans
Incidence
Japan
/ epidemiology
Male
Meningitis, Pneumococcal
/ epidemiology
Middle Aged
Mutation
Pneumococcal Infections
/ epidemiology
Pneumococcal Vaccines
Serogroup
Splenectomy
/ adverse effects
Streptococcus pneumoniae
/ genetics
Time Factors
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 02 2022
23 02 2022
Historique:
received:
09
09
2021
accepted:
09
02
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
19
3
2022
Statut:
epublish
Résumé
We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014-2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016-2018 was 0.20-0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27-4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10-5.06) or 23A (aOR 3.91, 95% CI 2.47-6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44-0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51-5.65).
Identifiants
pubmed: 35197497
doi: 10.1038/s41598-022-06950-w
pii: 10.1038/s41598-022-06950-w
pmc: PMC8866494
doi:
Substances chimiques
13-valent pneumococcal vaccine
0
Pneumococcal Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3066Investigateurs
Bin Chang
(B)
Kosuke Tamura
(K)
Hiroyuki Fujikura
(H)
Hiroshi Watanabe
(H)
Yoshinari Tanabe
(Y)
Koji Kuronuma
(K)
Jiro Fujita
(J)
Kengo Oshima
(K)
Takaya Maruyama
(T)
Shuichi Abe
(S)
Kei Kasahara
(K)
Junichiro Nishi
(J)
Tetsuya Kubota
(T)
Yuki Kinjo
(Y)
Yusuke Serizawa
(Y)
Reiko Shimbashi
(R)
Munehisa Fukusumi
(M)
Tomoe Shimada
(T)
Tomimasa Sunagawa
(T)
Motoi Suzuki
(M)
Kazunori Oishi
(K)
Kenji Gotoh
(K)
Chikako Tsubata
(C)
Hiroki Takahashi
(H)
Tetsuji Aoyagi
(T)
Masashi Nakamatsu
(M)
Naoko Imuta
(N)
Akihito Yokoyama
(A)
Hiroaki Takeda
(H)
Masayuki Ishida
(M)
Informations de copyright
© 2022. The Author(s).
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