Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs.
CD4-positive T cells
HIV infections
HIV reservoir
T-helper 17 cells
lymphocytes
mucosal immunology
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
11
2021
accepted:
14
01
2022
entrez:
24
2
2022
pubmed:
25
2
2022
medline:
23
3
2022
Statut:
epublish
Résumé
Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly susceptible to HIV-1 infection and are rapidly depleted from gut mucosal sites, causing an imbalance of the Th17/Treg ratio and impairing cytokines production. Consequently, damage to the gut mucosal barrier leads to an enhanced microbial translocation and systemic inflammation, a hallmark of HIV-1 disease progression. Th17 cells' expression of mucosal homing receptors (CCR6 and α4β7), as well as HIV receptors and co-receptors (CD4, α4β7, CCR5, and CXCR4), contributes to susceptibility to HIV infection. The up-regulation of numerous intracellular factors facilitating HIV production, alongside the downregulation of factors inhibiting HIV, helps to explain the frequency of HIV DNA within Th17 cells. Th17 cells harbor long-lived viral reservoirs in people living with HIV (PLWH) receiving antiretroviral therapy (ART). Moreover, cell longevity and the proliferation of a fraction of Th17 CD4 T cells allow HIV reservoirs to be maintained in ART patients.
Identifiants
pubmed: 35197986
doi: 10.3389/fimmu.2022.822576
pmc: PMC8858966
doi:
Substances chimiques
CXCR4 protein, human
0
Cytokines
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
822576Informations de copyright
Copyright © 2022 Renault, Veyrenche, Mennechet, Bedin, Routy, Van de Perre, Reynes and Tuaillon.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Science. 2015 Jan 23;347(6220):400-6
pubmed: 25477212
Nat Immunol. 2009 Aug;10(8):857-63
pubmed: 19578369
J Cell Biol. 2009 Jul 27;186(2):255-68
pubmed: 19635843
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17034-9
pubmed: 17942669
EMBO J. 2007 Jan 24;26(2):516-26
pubmed: 17215865
Exp Ther Med. 2018 Mar;15(3):2879-2883
pubmed: 29456692
Immunity. 2006 Feb;24(2):179-89
pubmed: 16473830
Cell Rep. 2012 Apr 19;1(4):360-73
pubmed: 22832227
J Infect Dis. 2010 Mar 15;201(6):843-54
pubmed: 20144043
PLoS Pathog. 2019 Jun 20;15(6):e1007868
pubmed: 31220191
Exp Cell Res. 2011 Mar 10;317(5):613-9
pubmed: 21376174
Cell Host Microbe. 2008 Oct 16;4(4):337-49
pubmed: 18854238
Mol Cell. 2003 Sep;12(3):591-601
pubmed: 14527406
Immunity. 2005 May;22(5):621-31
pubmed: 15894279
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7797-802
pubmed: 18509048
Clin Cancer Res. 2010 Oct 1;16(19):4695-701
pubmed: 20688898
EBioMedicine. 2021 Mar;65:103270
pubmed: 33662832
Eur J Immunol. 2010 Aug;40(8):2174-81
pubmed: 20486123
Front Immunol. 2011 Aug 30;2:36
pubmed: 22566826
PLoS Pathog. 2009 May;5(5):e1000437
pubmed: 19478882
Clin Infect Dis. 2020 Dec 31;71(11):e735-e743
pubmed: 32348459
Immunity. 2008 Jul 18;29(1):44-56
pubmed: 18585065
Cell Res. 2013 Jul;23(7):876-85
pubmed: 23732522
AIDS. 2019 May 1;33(6):985-991
pubmed: 30946152
AIDS. 2010 Feb 20;24(4):491-502
pubmed: 20071976
J Immunol. 2012 Jun 1;188(11):5438-47
pubmed: 22539793
J Immunol. 2011 Dec 1;187(11):6032-42
pubmed: 22048765
PLoS One. 2012;7(6):e39750
pubmed: 22768117
PLoS One. 2011;6(12):e28118
pubmed: 22162758
PLoS Pathog. 2009 Oct;5(10):e1000646
pubmed: 19876388
Cytometry B Clin Cytom. 2016 Nov;90(6):486-492
pubmed: 26666875
Biochim Biophys Acta. 2011 Oct;1813(10):1836-44
pubmed: 21745501
AIDS Res Hum Retroviruses. 2012 Apr;28(4):339-45
pubmed: 21767239
AIDS. 2015 Mar 13;29(5):519-30
pubmed: 25715102
Immunity. 2000 Nov;13(5):715-25
pubmed: 11114383
Genes Dev. 2004 Aug 15;18(16):1926-45
pubmed: 15314020
Retrovirology. 2015 Dec 10;12:102
pubmed: 26654242
Viruses. 2017 Oct 19;9(10):
pubmed: 29048384
Immunity. 2011 Dec 23;35(6):972-85
pubmed: 22177921
Mucosal Immunol. 2008 Nov;1(6):475-88
pubmed: 19079215
J Clin Invest. 2020 Nov 2;130(11):5847-5857
pubmed: 33016926
Mucosal Immunol. 2017 Jan;10(1):35-45
pubmed: 27049062
J Infect Dis. 2015 Aug 1;212(3):355-66
pubmed: 25616404
J Immunol. 2010 Feb 1;184(3):1604-16
pubmed: 20042588
J Exp Med. 2007 Aug 6;204(8):1849-61
pubmed: 17635957
Infect Immun. 2010 Jan;78(1):32-8
pubmed: 19901061
J Virol. 2019 Apr 17;93(9):
pubmed: 30787150
Physiol Rev. 2012 Oct;92(4):1619-49
pubmed: 23073628
Curr Opin HIV AIDS. 2019 Mar;14(2):85-92
pubmed: 30543544
J Biol Chem. 2003 Jan 17;278(3):1910-4
pubmed: 12417590
Eur J Immunol. 2008 Jul;38(7):1788-94
pubmed: 18581335
Cell. 2002 Dec 13;111(6):853-66
pubmed: 12526811
J Clin Immunol. 2001 May;21(3):171-4
pubmed: 11403223
J Immunol. 2012 Oct 15;189(8):3815-21
pubmed: 22988032
Ann N Y Acad Sci. 2013 Mar;1280:30-4
pubmed: 23551100
Immunity. 2011 Jul 22;35(1):13-22
pubmed: 21777796
J Immunol. 2007 Oct 1;179(7):4357-66
pubmed: 17878330
Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):
pubmed: 34819367
J Intern Med. 2017 May;281(5):422-432
pubmed: 28139864
AIDS. 2020 May 1;34(6):833-848
pubmed: 32044843
J Immunol. 2011 May 15;186(10):5758-65
pubmed: 21478400
Immunobiology. 2018 Nov;223(11):658-662
pubmed: 30005971
J Clin Invest. 2001 Jan;107(2):143-51
pubmed: 11160127
Viral Immunol. 2007 Spring;20(1):66-75
pubmed: 17425422
PLoS One. 2020 Feb 5;15(2):e0228745
pubmed: 32023301
Mucosal Immunol. 2009 Sep;2(5):403-11
pubmed: 19587639
Nat Immunol. 2008 Mar;9(3):301-9
pubmed: 18264102
Trends Immunol. 2013 Apr;34(4):151-4
pubmed: 23266231
AIDS. 2017 Jan 2;31(1):35-48
pubmed: 27835617
Front Immunol. 2021 Apr 15;12:664371
pubmed: 33936102
J Immunol. 2011 Apr 15;186(8):4618-30
pubmed: 21398606
PLoS Med. 2006 Dec;3(12):e484
pubmed: 17147468
J Acquir Immune Defic Syndr. 2015 Jan 1;68(1):6-12
pubmed: 25296095
J Exp Med. 2014 Jan 13;211(1):89-104
pubmed: 24395888
Nat Med. 2014 Jan;20(1):62-8
pubmed: 24362934
Cells. 2020 Apr 28;9(5):
pubmed: 32354054
Blood. 2008 Oct 1;112(7):2826-35
pubmed: 18664624
JCI Insight. 2017 Aug 3;2(15):
pubmed: 28768913
Curr Top Microbiol Immunol. 1996;205:63-87
pubmed: 8575198
J Virol. 2016 Aug 12;90(17):7833-47
pubmed: 27334595
Annu Rev Immunol. 2009;27:485-517
pubmed: 19132915
J Immunol Res. 2015;2015:647916
pubmed: 26568963
PLoS Pathog. 2019 Feb 27;15(2):e1007619
pubmed: 30811499
J Virus Erad. 2021 Feb 15;7(1):100033
pubmed: 33664976
J Transl Med. 2011 Jan 27;9 Suppl 1:S2
pubmed: 21284901
J Immunol. 2010 May 15;184(10):5519-26
pubmed: 20400707
Nat Immunol. 2019 Aug;20(8):1059-1070
pubmed: 31308541
Semin Immunol. 2007 Dec;19(6):377-82
pubmed: 18054248
J Virol. 2013 Oct;87(19):10843-54
pubmed: 23903844
Nat Immunol. 2012 Feb 12;13(3):223-228
pubmed: 22327569
PLoS One. 2013 Oct 16;8(10):e78146
pubmed: 24147117
Cell Host Microbe. 2016 Dec 14;20(6):785-797
pubmed: 27978436
Nat Immunol. 2006 Mar;7(3):235-9
pubmed: 16482171
Semin Immunol. 2004 Feb;16(1):3-9
pubmed: 14751757
Arthritis Rheum. 2011 Aug;63(8):2504-15
pubmed: 21381000
Front Immunol. 2021 Apr 12;12:656414
pubmed: 33912183
Nat Immunol. 2007 Sep;8(9):942-9
pubmed: 17676045
Immunobiology. 1995 Jul;193(2-4):193-203
pubmed: 8530143
J Virol. 2017 Jan 31;91(4):
pubmed: 27928019
Immunity. 2018 Jun 19;48(6):1183-1194.e5
pubmed: 29802019
Immunity. 2019 Apr 16;50(4):892-906
pubmed: 30995505
Sci Rep. 2019 Feb 13;9(1):1978
pubmed: 30760809
Nature. 2008 May 8;453(7192):236-40
pubmed: 18368049
Annu Rev Med. 2011;62:127-39
pubmed: 21054171
J Exp Med. 2007 May 14;204(5):995-1001
pubmed: 17470641
J Virol. 2015 Nov;89(22):11284-93
pubmed: 26339043
Curr Opin Immunol. 2007 Jun;19(3):281-6
pubmed: 17433650
J Immunol. 2013 Sep 1;191(5):2164-73
pubmed: 23894197
J Exp Med. 2008 Aug 4;205(8):1903-16
pubmed: 18663128
Nat Immunol. 2007 Jun;8(6):639-46
pubmed: 17486092
mBio. 2019 Oct 8;10(5):
pubmed: 31594817
Semin Immunol. 2003 Jun;15(3):177-83
pubmed: 14563116
AIDS. 2011 Mar 27;25(6):741-9
pubmed: 21378536
Lancet. 1995 Aug 5;346(8971):352-6
pubmed: 7623535
J Acquir Immune Defic Syndr. 2011 Jun 1;57(2):101-8
pubmed: 21407087
Gastroenterol Clin Biol. 2008 Mar;32(3):354-6
pubmed: 18374530
J Immunol. 2008 Apr 15;180(8):5167-71
pubmed: 18390697
Retrovirology. 2016 Aug 24;13(1):59
pubmed: 27553844
AIDS. 2008 May 11;22(8):990-2
pubmed: 18453860
Curr Opin HIV AIDS. 2010 Mar;5(2):135-40
pubmed: 20543590
Mucosal Immunol. 2014 Nov;7(6):1375-85
pubmed: 24759207
J Infect Dis. 2008 Mar 1;197(5):714-20
pubmed: 18260759
Trends Cell Biol. 2010 Mar;20(3):160-9
pubmed: 20071173
Nucl Recept Signal. 2009;7:e003
pubmed: 19381306
Blood. 2011 Jan 27;117(4):1250-9
pubmed: 21084709
Nat Immunol. 2005 Nov;6(11):1123-32
pubmed: 16200070