Pharmacology and toxicology of tannins.
Complex tannins
Ellagitannins
Gallotannins
Pharmacological activities
Proanthocyanidins
Toxicology
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
07
12
2021
accepted:
07
02
2022
pubmed:
25
2
2022
medline:
20
4
2022
entrez:
24
2
2022
Statut:
ppublish
Résumé
Tannins are an interesting class of polyphenols, characterized, in almost all cases, by a different degree of polymerization, which, inevitably, markedly influences their bioavailability, as well as biochemical and pharmacological activities. They have been used for the process of tanning to transform hides into leather, from which their name derives. For several time, they have not been accurately evaluated, but now researchers have started to unravel their potential, highlighting anti-inflammatory, antimicrobial, antioxidant and anticancer activities, as well as their involvement in cardiovascular, neuroprotective and in general metabolic diseases prevention. The mechanisms underlying their activity are often complex, but the main targets of their action (such as key enzymes modulation, activation of metabolic pathways and changes in the metabolic fluxes) are highlighted in this review, without losing sight of their toxicity. This aspect still needs further and better-designed study to be thoroughly understood and allow a more conscious use of tannins for human health.
Identifiants
pubmed: 35199243
doi: 10.1007/s00204-022-03250-0
pii: 10.1007/s00204-022-03250-0
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Polyphenols
0
Tannins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1257-1277Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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