Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling.

Cobra Cardiotoxin Proteins / chemistry Crystallography, X-Ray / methods Cytotoxins / chemistry Models, Molecular Molecular Structure Protein Conformation
Highly Mimetic Membrane Model Naja naja venom X-ray crystallography cis–trans isomerism of X-Pro peptide bond cobra cytotoxin molecular dynamics

Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
18 02 2022
Historique:
received: 29 12 2021
revised: 05 02 2022
accepted: 16 02 2022
entrez: 24 2 2022
pubmed: 25 2 2022
medline: 19 3 2022
Statut: epublish

Résumé

Cobra cytotoxins (CTs) belong to the three-fingered protein family and possess membrane activity. Here, we studied cytotoxin 13 from

Identifiants

DOI: 10.3390/toxins14020149 PMID: 35202176 PMC: PMC8880459
pubmed: 35202176
pii: toxins14020149
doi: 10.3390/toxins14020149
pmc: PMC8880459
pii:
doi:

Substances chimiques

Cobra Cardiotoxin Proteins 0
Cytotoxins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Peter V Dubovskii (PV)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.

Kira M Dubova (KM)

FSRC "Crystallography and Photonics", Russian Academy of Sciences, 111933 Moscow, Russia.
NRC "Kurchatov Institute", 123182 Moscow, Russia.

Gleb Bourenkov (G)

European Molecular Biology Laboratory, Hamburg Unit, c/o DESY, 22607 Hamburg, Germany.

Vladislav G Starkov (VG)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.

Anastasia G Konshina (AG)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.

Roman G Efremov (RG)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.
Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., 141700 Dolgoprudny, Russia.
Higher School of Economics, National Research University, 20 Myasnitskaya str., 101000 Moscow, Russia.

Yuri N Utkin (YN)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., 117997 Moscow, Russia.
ORCID: 0000-0002-4609-970X

Valeriya R Samygina (VR)

FSRC "Crystallography and Photonics", Russian Academy of Sciences, 111933 Moscow, Russia.
NRC "Kurchatov Institute", 123182 Moscow, Russia.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de serpent › Venins des élapidés › Cardiotoxines de venin de cobra › Variability in the Spatial Structure of the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Variability in the Spatial Structure of the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Cytotoxines › Variability in the Spatial Structure of the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Variability in the Spatial Structure of the...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Variability in the Spatial Structure of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Variability in the Spatial Structure of the...