Epigenetic Dysregulation of the
DNA methylation
T2D familiarity
adipocyte hypertrophy
adipose tissue
epigenetic marks
gene expression
human adipogenesis
obesity
preadipocyte
transcription factors
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
18 02 2022
18 02 2022
Historique:
received:
30
01
2022
accepted:
14
02
2022
entrez:
25
2
2022
pubmed:
26
2
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose tissue (SAT) and subcutaneous adipocyte hypertrophy well before diabetes onset. The molecular mechanisms linking these events have only partially been clarified. In the present report, we show that silencing of the transcription factor
Identifiants
pubmed: 35203377
pii: cells11040728
doi: 10.3390/cells11040728
pmc: PMC8870634
pii:
doi:
Substances chimiques
HOXA5 protein, human
0
Homeodomain Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, Università e della Ricerca Scientifica
ID : PRIN 2017
Organisme : Regione Campania
ID : POR FESR 2014-2020 - Obiettivo Specifico 1.2. - "Manifestazione di Interesse per la Real-izzazione di Technology Platform nell'ambito della Lotta alle Patologie Oncologiche" - Projects COEPICA, RARE PLAT NET and SATIN
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