Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.

Alleles Brugada Syndrome / complications Disease Susceptibility / complications Genetic Predisposition to Disease Genome-Wide Association Study Humans Microtubule-Associated Proteins / genetics Mutation NAV1.5 Voltage-Gated Sodium Channel / genetics Young Adult

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
03 2022
Historique:
received: 25 09 2020
accepted: 13 12 2021
pubmed: 26 2 2022
medline: 28 4 2022
entrez: 25 2 2022
Statut: ppublish

Résumé

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na

Identifiants

DOI: 10.1038/s41588-021-01007-6 PMID: 35210625 PMC: PMC9376964
pubmed: 35210625
doi: 10.1038/s41588-021-01007-6
pii: 10.1038/s41588-021-01007-6
pmc: PMC9376964
mid: NIHMS1817393
doi:

Substances chimiques

MAPRE2 protein, human 0
Microtubule-Associated Proteins 0
NAV1.5 Voltage-Gated Sodium Channel 0

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

232-239

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL047678
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL092577
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG010464
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134328
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM115305
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152201
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149826
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL105780
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL127704
Pays : United States
Organisme : Wellcome Trust
ID : 076113
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R56 HL138103
Pays : United States
Organisme : British Heart Foundation
ID : FS/11/71/28918
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL128914
Pays : United States
Organisme : Wellcome Trust
ID : 085475
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 090355
Pays : United Kingdom

Investigateurs

Konstantin Strauch (K)
Annette Peters (A)
Holger Schulz (H)
Lars Schwettmann (L)
Reiner Leidl (R)
Margit Heier (M)
Pascal Defaye (P)
Frédéric Anselme (F)
Jean Philippe Darmon (JP)
François Wiart (F)

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

Références

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Auteurs

Julien Barc (J)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France. julien.barc@univ-nantes.fr.
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . julien.barc@univ-nantes.fr.
ORCID: 0000-0003-4106-5946

Rafik Tadros (R)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
ORCID: 0000-0002-1472-0258

Charlotte Glinge (C)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

David Y Chiang (DY)

Medicine, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
ORCID: 0000-0002-5883-6383

Mariam Jouni (M)

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Floriane Simonet (F)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Sean J Jurgens (SJ)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-1605-9782

Manon Baudic (M)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Michele Nicastro (M)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
ORCID: 0000-0002-4136-2599

Franck Potet (F)

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Joost A Offerhaus (JA)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Roddy Walsh (R)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
ORCID: 0000-0001-5092-8825

Seung Hoan Choi (SH)

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-2797-3190

Arie O Verkerk (AO)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
ORCID: 0000-0003-2140-834X

Yuka Mizusawa (Y)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Soraya Anys (S)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Damien Minois (D)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Marine Arnaud (M)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Josselin Duchateau (J)

IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
Université Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
Electrophysiology and Ablation Unit, Bordeaux University Hospital (CHU), Pessac, France.

Yanushi D Wijeyeratne (YD)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Cardiology Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust, London, UK.

Alison Muir (A)

Cardiology, Belfast Health and Social Care Trust and Queen's University Belfast, Belfast, UK.

Michael Papadakis (M)

Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Cardiology Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust, London, UK.

Silvia Castelletti (S)

Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano IRCCS, Milan, Italy.

Margherita Torchio (M)

Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy.

Cristina Gil Ortuño (CG)

Cardiogenetic, Unidad de Cardiopatías Familiares, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Murcia, Spain.
ORCID: 0000-0001-7296-3445

Javier Lacunza (J)

Cardiology, Unidad de Cardiopatías Familiares, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain.

Daniela F Giachino (DF)

Clinical and Biological Sciences, Medical Genetics, University of Torino, Orbassano, Italy.
Medical Genetics, San Luigi Gonzaga University Hospital, Orbassano, Italy.
ORCID: 0000-0002-3186-6726

Natascia Cerrato (N)

Medical Sciences, Cardiology, University of Torino, Torino, Italy.

Raphaël P Martins (RP)

Cardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.

Oscar Campuzano (O)

Cardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain.
Medical Science Department, University of Girona, Girona, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Biochemistry and Molecular Genetics Department, Hospital Clinic, University of Barcelona-IDIBAPS, Barcelona, Spain.
ORCID: 0000-0001-5298-5276

Sonia Van Dooren (S)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Centre for Medical Genetics, research group Reproduction and Genetics, research cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

Aurélie Thollet (A)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Florence Kyndt (F)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Andrea Mazzanti (A)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Molecular Cardiology, ICS Maugeri, IRCCS and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Nicolas Clémenty (N)

Department of Cardiology, CHU Tours, Tours, France.

Arnaud Bisson (A)

Department of Cardiology, CHU Tours, Tours, France.
ORCID: 0000-0002-3449-1800

Anniek Corveleyn (A)

Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.

Birgit Stallmeyer (B)

University Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.

Sven Dittmann (S)

University Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.

Johan Saenen (J)

Cardiology, Electrophysiology - Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.

Antoine Noël (A)

Department of Cardiology, University Hospital of Brest, Brest, France.

Shohreh Honarbakhsh (S)

Cardiology, Medicine, Barts Heart Centre, London, UK.

Boris Rudic (B)

Department 1st of Medicine, Cardiology, University Medical Center Mannheim, Mannheim, Germany.
German Center for Cardiovascular Research (DZHK), Mannheim, Germany.

Halim Marzak (H)

Department of Cardiology, University Hospital of Strasbourg, Strasbourg, France.

Matthew K Rowe (MK)

Medicine, Cardiology, Western University, London, Ontario, Canada.

Claire Federspiel (C)

Department of Cardiovascular Medicine, Vendée Hospital, Service de Cardiologie, La Roche sur Yon, France.

Sophie Le Page (S)

Service de cardiologie, CHU Angers, Angers, France.

Leslie Placide (L)

Department of Cardiology, CHU Montpellier, Montpellier, France.

Antoine Milhem (A)

Department of Cardiology, CH La Rochelle, La Rochelle, France.

Hector Barajas-Martinez (H)

Lankenau Institute for Medical Research, Wynnewood, PA, USA.
ORCID: 0000-0002-2704-3807

Britt-Maria Beckmann (BM)

Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
University Hospital of the Johann Wolfgang Goethe University Frankfurt, Institute of Legal Medicine, Frankfurt, Germany.
ORCID: 0000-0003-4176-4050

Ingrid P Krapels (IP)

Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.

Johannes Steinfurt (J)

Department of Cardiology and Angiology I, Heart Center, University Freiburg, Freiburg, Germany.

Bo Gregers Winkel (BG)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Reza Jabbari (R)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Moore B Shoemaker (MB)

Medicine, Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.

Bas J Boukens (BJ)

Department of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Doris Škorić-Milosavljević (D)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Hennie Bikker (H)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Genome Diagnostics Laboratory, Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands.

Federico Manevy (F)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Peter Lichtner (P)

Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

Marta Ribasés (M)

Psychiatric Genetics Unit, Institute Vall d'Hebron Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Thomas Meitinger (T)

Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

Martina Müller-Nurasyid (M)

Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
IBE, LMU Munich, Munich, Germany.
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
ORCID: 0000-0003-3793-5910

Jan H Veldink (JH)

Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
ORCID: 0000-0001-5572-9657

Leonard H van den Berg (LH)

Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Philip Van Damme (P)

Neurology Department University Hospital Leuven, Neuroscience Department KU Leuven, Center for Brain & Disease Research VIB, Leuven, Belgium.
ORCID: 0000-0002-4010-2357

Daniele Cusi (D)

Scientific Unit, Bio4Dreams - Business Nursery for Life Sciences, Milan, Italy.

Chiara Lanzani (C)

Nephrology, Genomics of Renal Diseases and Hypertension Unit, Università Vita Salute San Raffaele, Milan, Italy.

Sidwell Rigade (S)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Eric Charpentier (E)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.

Estelle Baron (E)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
ORCID: 0000-0002-5509-3086

Stéphanie Bonnaud (S)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.

Simon Lecointe (S)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
ORCID: 0000-0002-1785-7735

Audrey Donnart (A)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.

Hervé Le Marec (H)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Stéphanie Chatel (S)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Matilde Karakachoff (M)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.

Stéphane Bézieau (S)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
ORCID: 0000-0003-0095-1319

Barry London (B)

Department of Internal Medicine, Division of Cardiovascular Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Jacob Tfelt-Hansen (J)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.

Dan Roden (D)

Medicine, Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Medicine, Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Medicine, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Katja E Odening (KE)

Department of Cardiology and Angiology I, Heart Center, University Freiburg, Freiburg, Germany.
Department of Cardiology, Translational Cardiology, University Hospital Bern, Bern, Switzerland.

Marina Cerrone (M)

Medicine, Leon H. Charney Division of Cardiology, Heart Rhythm Center and Cardiovascular Genetics Program, New York University School of Medicine, New York, NY, USA.

Larry A Chinitz (LA)

Medicine, Leon H. Charney Division of Cardiology, Heart Rhythm Center and Cardiovascular Genetics Program, New York University School of Medicine, New York, NY, USA.

Paul G Volders (PG)

Department of Cardiology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands.

Maarten P van de Berg (MP)

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-1493-2998

Gabriel Laurent (G)

Cardiology Department, ImVia lab team IFTIM, University Hospital Dijon, Dijon, France.

Laurence Faivre (L)

Centre de Génétique, FHU TRANSLAD, Dijon, France.

Charles Antzelevitch (C)

Lankenau Institute for Medical Research, Wynnewood, PA, USA.

Stefan Kääb (S)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
German Center for Cardiovascular Research (DZHK), Partnersite Munich, Munich, Germany.

Alain Al Arnaout (AA)

Department of Cardiology, CH La Rochelle, La Rochelle, France.

Jean-Marc Dupuis (JM)

Service de cardiologie, CHU Angers, Angers, France.

Jean-Luc Pasquie (JL)

Department of Cardiology, CNRS UMR9214 - Inserm U1046 - PHYMEDEXP, Université de Montpellier et CHU Montpellier, Montpellier, France.

Olivier Billon (O)

Department of Cardiovascular Medicine, Vendée Hospital, Service de Cardiologie, La Roche sur Yon, France.

Jason D Roberts (JD)

Medicine, Cardiology, Western University, London, Ontario, Canada.

Laurence Jesel (L)

Department of Cardiology, University Hospital of Strasbourg, Strasbourg, France.
INSERM 1260 - Regenerative Nanomedecine, University of Strasbourg, Strasbourg, France.

Martin Borggrefe (M)

Department 1st of Medicine, Cardiology, University Medical Center Mannheim, Mannheim, Germany.
German Center for Cardiovascular Research (DZHK), Mannheim, Germany.

Pier D Lambiase (PD)

Cardiology, Medicine, Barts Heart Centre, London, UK.
Institute of Cardiovasculr Science, UCL, Population Health, UCL, London, UK.

Jacques Mansourati (J)

Department of Cardiology, University Hospital of Brest, Brest, France.

Bart Loeys (B)

Center for Medical Genetics, Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.

Antoine Leenhardt (A)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Department of Cardiology, Hopital Bichat, Paris, France.

Pascale Guicheney (P)

Sorbonne Université, Paris, France.
UMR_S1166, Faculté de médecine, Sorbonne Université, INSERM, Paris, France.

Philippe Maury (P)

Service de cardiologie, Hôpital Rangueil, CHU de Toulouse, Toulouse, France.

Eric Schulze-Bahr (E)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
University Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.

Tomas Robyns (T)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

Jeroen Breckpot (J)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.
ORCID: 0000-0002-0734-5154

Dominique Babuty (D)

Department of Cardiology, CHU Tours, Tours, France.

Silvia G Priori (SG)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Molecular Cardiology, ICS Maugeri, IRCCS and Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Carlo Napolitano (C)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Molecular Cardiology, ICS Maugeri, IRCCS and Department of Molecular Medicine, University of Pavia, Pavia, Italy.
ORCID: 0000-0002-7643-4628

Carlo de Asmundis (C)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and Pacing Universitair Ziekenhuis, Brussel-Vrije Universiteit Brussel, ERN Heart Guard Center, Brussels, Belgium.
IDIBAPS, Institut d'Investigació August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
ORCID: 0000-0001-9351-0760

Pedro Brugada (P)

Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium.

Ramon Brugada (R)

Hospital Trueta, CiberCV, University of Girona, IDIBGI, Girona, Spain, Barcelona, Spain.

Elena Arbelo (E)

Arrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
ORCID: 0000-0003-0424-6393

Josep Brugada (J)

Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Philippe Mabo (P)

Cardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.

Nathalie Behar (N)

Cardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.

Carla Giustetto (C)

Medical Sciences, Cardiology, University of Torino, Torino, Italy.

Maria Sabater Molina (MS)

Cardiogenetic, Unidad de Cardiopatías Familiares, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Murcia, Spain.
ORCID: 0000-0003-1352-1748

Juan R Gimeno (JR)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Cardiology, Unidad de Cardiopatías Familiares, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain.

Can Hasdemir (C)

Department of Cardiology, Ege University School of Medicine, Bornova, Turkey.

Peter J Schwartz (PJ)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy.
ORCID: 0000-0003-0367-1048

Lia Crotti (L)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy.
Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Pascal P McKeown (PP)

Cardiology, Belfast Health and Social Care Trust and Queen's University Belfast, Belfast, UK.
ORCID: 0000-0001-7488-3094

Sanjay Sharma (S)

Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Cardiology Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust, London, UK.

Elijah R Behr (ER)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Cardiology Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust, London, UK.
ORCID: 0000-0002-8731-2853

Michel Haissaguerre (M)

IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
Université Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
Electrophysiology and Ablation Unit, Bordeaux University Hospital (CHU), Pessac, France.

Frédéric Sacher (F)

IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
Université Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
Electrophysiology and Ablation Unit, Bordeaux University Hospital (CHU), Pessac, France.

Caroline Rooryck (C)

CHU Bordeaux, Service de Génétique Médicale, Bordeaux, France.
Université de Bordeaux, Maladies Rares: Génétique et Métabolisme (MRGM), INSERM U1211, Bordeaux, France.

Hanno L Tan (HL)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Netherlands Heart Institute, Utrecht, The Netherlands.

Carol A Remme (CA)

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Pieter G Postema (PG)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Mario Delmar (M)

Medicine, Cardiology, New York University School of Medicine, New York, NY, USA.

Patrick T Ellinor (PT)

Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital and Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Boston, MA, USA.
ORCID: 0000-0002-2067-0533

Steven A Lubitz (SA)

Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital and Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Boston, MA, USA.
ORCID: 0000-0002-9599-4866

Jean-Baptiste Gourraud (JB)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.

Michael W Tanck (MW)

Clinical Epidemiology, Biostatistics and Bioinformatics, Clinical Methods and Public Health, Amsterdam Public Health, Amsterdam, The Netherlands.
ORCID: 0000-0001-9828-4459

Alfred L George (AL)

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
ORCID: 0000-0002-3993-966X

Calum A MacRae (CA)

Medicine, Cardiovascular Medicine, Genetics and Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Paul W Burridge (PW)

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
ORCID: 0000-0001-9616-0006

Christian Dina (C)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
ORCID: 0000-0002-7722-7348

Vincent Probst (V)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.

Arthur A Wilde (AA)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Jean-Jacques Schott (JJ)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
ORCID: 0000-0002-9578-9475

Richard Redon (R)

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
ORCID: 0000-0001-7751-2280

Connie R Bezzina (CR)

European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . c.r.bezzina@amsterdamumc.nl.
Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. c.r.bezzina@amsterdamumc.nl.
ORCID: 0000-0002-0633-3514

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Genome-wide association analyses identify new...
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questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Genome-wide association analyses identify new...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide association analyses identify new...
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