Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema.
Journal
Clinical and translational science
ISSN: 1752-8062
Titre abrégé: Clin Transl Sci
Pays: United States
ID NLM: 101474067
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
13
12
2021
received:
15
09
2021
accepted:
19
12
2021
pubmed:
26
2
2022
medline:
19
4
2022
entrez:
25
2
2022
Statut:
ppublish
Résumé
Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by recurrent episodes of swelling of the skin, larynx, gastrointestinal tract, genitals, and extremities that can be disruptive to patient quality of life. Dysregulation of plasma kallikrein activity leads to increased production and accumulation of bradykinin in HAE and causes attacks of angioedema. Plasma kallikrein is a serine protease essential for the formation of bradykinin. Berotralstat is a potent, highly selective, orally bioavailable small-molecule plasma kallikrein inhibitor that has been approved to prevent attacks of HAE in adults and children 12 years of age and older. Population pharmacokinetic (PK) analyses were conducted to describe the PK of berotralstat (BCX7353; Orladeyo
Identifiants
pubmed: 35212456
doi: 10.1111/cts.13233
pmc: PMC9010267
doi:
Substances chimiques
Pyrazoles
0
Plasma Kallikrein
EC 3.4.21.34
Bradykinin
S8TIM42R2W
berotralstat
XZA0KB1BDQ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1027-1035Informations de copyright
© 2022 BioCryst Pharmaceuticals, Inc. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics.
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