Genetic Biomarkers of Metabolic Detoxification for Personalized Lifestyle Medicine.
LIFEHOUSE study
biomarkers
biotransformation
detoxification
environmental health
functional medicine
nutrigenomics
personalized lifestyle medicine
pragmatic clinical trials
single nucleotide polymorphisms
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
11 Feb 2022
11 Feb 2022
Historique:
received:
18
01
2022
revised:
07
02
2022
accepted:
08
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
3
3
2022
Statut:
epublish
Résumé
Metabolic detoxification (detox)-or biotransformation-is a physiological function that removes toxic substances from our body. Genetic variability and dietary factors may affect the function of detox enzymes, thus impacting the body's sensitivity to toxic substances of endogenous and exogenous origin. From a genetic perspective, most of the current knowledge relies on observational studies in humans or experimental models in vivo and in vitro, with very limited proof of causality and clinical value. This review provides health practitioners with a list of single nucleotide polymorphisms (SNPs) located within genes involved in Phase I and Phase II detoxification reactions, for which evidence of clinical utility does exist. We have selected these SNPs based on their association with interindividual variability of detox metabolism in response to certain nutrients in the context of human clinical trials. In order to facilitate clinical interpretation and usage of these SNPs, we provide, for each of them, a strength of evidence score based on recent guidelines for genotype-based dietary advice. We also present the association of these SNPs with functional biomarkers of detox metabolism in a pragmatic clinical trial, the LIFEHOUSE study.
Identifiants
pubmed: 35215417
pii: nu14040768
doi: 10.3390/nu14040768
pmc: PMC8876337
pii:
doi:
Substances chimiques
Genetic Markers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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