Interferon-β Suppresses Transcriptionally Active Parvovirus B19 Infection in Viral Cardiomyopathy: A Subgroup Analysis of the BICC-Trial.
Adult
Aged
Cardiomyopathies
/ prevention & control
Endothelium, Vascular
/ drug effects
Female
Humans
Interferon-beta
/ pharmacology
Male
Middle Aged
Parvoviridae Infections
/ complications
Parvovirus B19, Human
/ drug effects
Prospective Studies
Retrospective Studies
Stroke Volume
/ drug effects
Ventricular Function, Left
human parvovirus B19
interferon beta-1b
transcriptional activity
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
21 02 2022
21 02 2022
Historique:
received:
11
01
2022
revised:
14
02
2022
accepted:
18
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Human parvovirus B19 (B19V) is the predominant virus currently detected in endomyocardial biopsies (EMBs). Recent findings indicate that, specifically, transcriptionally active B19V with detectable viral RNA is of prognostic relevance in inflammatory viral cardiomyopathy. We aimed to evaluate B19V replicative status (viral RNA) and beneficial effects in a sub-collective of the prospective randomized placebo-controlled phase II multi-center BICC-Trial (Betaferon In Chronic Viral Cardiomyopathy) after interferon beta-1b (IFN-β) treatment. EMBs of
Identifiants
pubmed: 35216037
pii: v14020444
doi: 10.3390/v14020444
pmc: PMC8875228
pii:
doi:
Substances chimiques
Interferon-beta
77238-31-4
Types de publication
Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Biomedicines. 2021 Dec 14;9(12):
pubmed: 34944716
N Engl J Med. 2010 Apr 1;362(13):1248-9
pubmed: 20357294
J Clin Med. 2021 Apr 29;10(9):
pubmed: 33946917
Clin Res Cardiol. 2016 Sep;105(9):763-73
pubmed: 27112783
Eur J Heart Fail. 2021 Feb;23(2):302-309
pubmed: 33347677
Sci Rep. 2020 Dec 18;10(1):22354
pubmed: 33339949
Eur J Heart Fail. 2019 Nov;21(11):1468-1469
pubmed: 31476088
ESC Heart Fail. 2020 Oct;7(5):2440-2447
pubmed: 32529795
Basic Res Cardiol. 2013 Sep;108(5):372
pubmed: 23934091
Eur J Heart Fail. 2016 Dec;18(12):1430-1441
pubmed: 27748022
J Card Fail. 2019 Jan;25(1):60-63
pubmed: 30103022
Hum Pathol. 2003 Jan;34(1):92-5
pubmed: 12605372
J Infect Dis. 2010 Mar 15;201(6):936-45
pubmed: 20158391
Mitochondrion. 2016 Sep;30:236-47
pubmed: 27562426
Nat Rev Dis Primers. 2019 May 9;5(1):32
pubmed: 31073128
Eur J Immunol. 2007 Dec;37(12):3334-8
pubmed: 18034430
J Clin Med. 2020 Aug 19;9(9):
pubmed: 32825201
Cardiovasc Res. 2021 Nov 22;117(13):2610-2623
pubmed: 34609508
Eur Heart J. 2013 Sep;34(33):2636-48, 2648a-2648d
pubmed: 23824828