A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.
FBXL3
circadian clock
rare genetic disease
zebrafish
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Feb 2022
21 Feb 2022
Historique:
received:
01
02
2022
revised:
17
02
2022
accepted:
18
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
22
3
2022
Statut:
epublish
Résumé
The circadian clock, which drives a wide range of bodily rhythms in synchrony with the day-night cycle, is based on a molecular oscillator that ticks with a period of approximately 24 h. Timed proteasomal degradation of clock components is central to the fine-tuning of the oscillator's period. FBXL3 is a protein that functions as a substrate-recognition factor in the E3 ubiquitin ligase complex, and was originally shown in mice to mediate degradation of CRY proteins and thus contribute to the mammalian circadian clock mechanism. By exome sequencing, we have identified a
Identifiants
pubmed: 35216494
pii: ijms23042373
doi: 10.3390/ijms23042373
pmc: PMC8875760
pii:
doi:
Substances chimiques
F-Box Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : German-Israeli Foundation for Scientific Research and Development
ID : I-1320-203.13/2015
Organisme : Helmholtz funding program, BioInterfaces in Technology and Medicine
Organisme : Israel Science Foundation
ID : 961/19
Organisme : Israel Science Foundation
ID : 2462/20
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