Malondialdehyde and anion patterns in exhaled breath condensate among subway workers.
Anion
Exhaled breath condensate
Exposure
Metabolism
Particulate matter
Underground
Journal
Particle and fibre toxicology
ISSN: 1743-8977
Titre abrégé: Part Fibre Toxicol
Pays: England
ID NLM: 101236354
Informations de publication
Date de publication:
25 02 2022
25 02 2022
Historique:
received:
14
12
2021
accepted:
14
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
15
4
2022
Statut:
epublish
Résumé
Underground transportation systems can contribute to the daily particulates and metal exposures for both commuter and subway workers. The redox and metabolic changes in workers exposed to such metal-rich particles have yet to be characterized. We hypothesize that the distribution of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) are modified depending on exposures. Particulate number and size as well as mass concentration and airborne metal content were measured in three groups of nine subway workers (station agents, locomotive operators and security guards). In parallel, pre- and post-shift EBC was collected daily during two consecutive working weeks. In this biological matrix, malondialdehyde, lactate, acetate, propionate, butyrate, formate, pyruvate, the sum of nitrite and nitrate (ΣNO These results are exploratory but suggest that exposure to subway PM could affect concentrations of nitrogen oxides as well as acetate and lactate in EBC of subway workers. The effect is modulated by the particle size and can correspond to the body's cellular responses under oxidative stress to maintain the redox and/or metabolic homeostasis.
Sections du résumé
BACKGROUND
Underground transportation systems can contribute to the daily particulates and metal exposures for both commuter and subway workers. The redox and metabolic changes in workers exposed to such metal-rich particles have yet to be characterized. We hypothesize that the distribution of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) are modified depending on exposures.
RESULTS
Particulate number and size as well as mass concentration and airborne metal content were measured in three groups of nine subway workers (station agents, locomotive operators and security guards). In parallel, pre- and post-shift EBC was collected daily during two consecutive working weeks. In this biological matrix, malondialdehyde, lactate, acetate, propionate, butyrate, formate, pyruvate, the sum of nitrite and nitrate (ΣNO
CONCLUSIONS
These results are exploratory but suggest that exposure to subway PM could affect concentrations of nitrogen oxides as well as acetate and lactate in EBC of subway workers. The effect is modulated by the particle size and can correspond to the body's cellular responses under oxidative stress to maintain the redox and/or metabolic homeostasis.
Identifiants
pubmed: 35216613
doi: 10.1186/s12989-022-00456-z
pii: 10.1186/s12989-022-00456-z
pmc: PMC8876786
doi:
Substances chimiques
Acetates
0
Anions
0
Biomarkers
0
Dust
0
Nitrates
0
Nitrites
0
Nitrogen Oxides
0
Particulate Matter
0
Lactic Acid
33X04XA5AT
Malondialdehyde
4Y8F71G49Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16Informations de copyright
© 2022. The Author(s).
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