Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 02 2022
25 02 2022
Historique:
received:
22
10
2021
accepted:
04
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Soil-transmitted helminth infections represent a large burden with over a quarter of the world's population at risk. Low cure rates are observed with standard of care (albendazole); therefore, a more effective combination therapy (albendazole and ivermectin) is being investigated but showed variable treatment efficacies without evidence of intrinsic parasite resistance. Here, we analyzed the microbiome of Trichuris trichiura and hookworm-infected patients and found an association of different enterotypes with treatment efficacy. 80 T. trichiura-infected patients with hookworm co-infections from Pak-Khan, Laos, received either albendazole (n = 41) or albendazole and ivermectin combination therapy (n = 39). Pre-/post-treatment stool samples were collected to monitor treatment efficacy and microbial communities were profiled using 16S rRNA gene sequencing, qPCR, and shotgun sequencing. We identified three bacterial enterotypes and show that pre-treatment enterotype is associated with efficacy of the combination treatment for both T. trichiura (CR
Identifiants
pubmed: 35217670
doi: 10.1038/s41467-022-28658-1
pii: 10.1038/s41467-022-28658-1
pmc: PMC8881608
doi:
Substances chimiques
Anthelmintics
0
RNA, Ribosomal, 16S
0
Soil
0
Ivermectin
70288-86-7
Albendazole
F4216019LN
Banques de données
ClinicalTrials.gov
['NCT03527732']
Types de publication
Clinical Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1063Informations de copyright
© 2022. The Author(s).
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