Cross-reactivity between microbial and tumor antigens.

Antigens, Neoplasm / metabolism Bacteria Gastrointestinal Microbiome Humans Immunotherapy T-Lymphocytes

Journal

Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118

Informations de publication

Date de publication:
04 2022
Historique:
received: 26 10 2021
revised: 19 12 2021
accepted: 16 02 2022
pubmed: 28 2 2022
medline: 11 5 2022
entrez: 27 2 2022
Statut: ppublish

Résumé

The composition of the gut microbiota has a major impact on anticancer immunosurveillance. This effect is in part determined by systemic effects of bacterial or fungal metabolites, as well as by microbial ligands of pattern recognition receptors that modulate adjuvant signals and hence determine the general immune tonus. In addition, microbial antigens can elicit specific T lymphocyte responses that are cross-reactive with respect to tumor-associated antigens, hence inducing specific antitumor immune responses. Here, we discuss current evidence in favor of such cross-reactive anticancer/antimicrobial T cell response and delineate a methodology to demonstrate their actual importance for the immune control of malignant cells.

Identifiants

DOI: 10.1016/j.coi.2022.102171 PMID: 35219942
pubmed: 35219942
pii: S0952-7915(22)00009-7
doi: 10.1016/j.coi.2022.102171
pii:
doi:

Substances chimiques

Antigens, Neoplasm 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102171

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Laurence Zitvogel (L)

Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Université Paris Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France; INSERM U1015, Paris, France; Equipe labellisée par la Ligue contre le Cancer, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) BIOTHERIS, Villejuif, France. Electronic address: Laurence.zitvogel@orange.fr.

Guido Kroemer (G)

Equipe labellisée par la Ligue contre le Cancer, Université de Paris, Sorbonne Université, Institut Universitaire de France, Inserm U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France. Electronic address: Kroemer@orange.fr.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Cross-reactivity between microbial and tumor antigens.
questionsmedicales.fr › Bactéries › Cross-reactivity between microbial and tumor antigens.
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Cross-reactivity between microbial and tumor antigens.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cross-reactivity between microbial and tumor antigens.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Cross-reactivity between microbial and tumor antigens.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cross-reactivity between microbial and tumor antigens.